Results 71 to 80 of about 24,013,578 (179)

S‑glutathionylation of MaWRKY44 orchestrates a MaZFP139‐MaWRKY44‐MaGSTU07 cascade to enhance banana cold tolerance

Journal of Integrative Plant Biology, EarlyView.
In banana, at low temperatures (7°C), the transcription factor MaZFP139 activates MaWRKY44 expression. MaWRKY44 binds to the W‐box sites in the promoter of the glutathione S‐transferase gene MaGSTU07 to enhance reactive oxygen species scavenging. S‐glutathionylation protects MaWRKY44 from oxidation‐induced degradation, reinforcing antioxidant defenses ...
Shuqin Lin, Wen Song, Shaoting Liao, Haike Tan, Jianji Qi, Danling Cai, Wei Wei, Wei Shan, Jianfei Kuang, Jianye Chen, Wangjin Lu   +10 more
wiley   +1 more source

Glutathione, glutathione disulfide, and S-glutathionylated proteins in cell cultures

Free Radical Biology and Medicine, 2015
The analysis of the global thiol-disulfide redox status in tissues and cells is a challenging task since thiols and disulfides can undergo artificial oxido-reductions during sample manipulation. Because of this, the measured values, in particular for disulfides, can have a significant bias. Whereas this methodological problem has already been addressed
GIUSTARINI, DANIELA, GALVAGNI, FEDERICO, Tesei, Anna, Farolfi, Alberto, Zanoni, Michele, Pignatta, Sara, Milzani, Aldo, Marone, Ilaria M., Dalle Donne, Isabella, Nassini, Romina, ROSSI, RANIERI   +10 more
openaire   +3 more sources

Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?

Redox Biology, 2021
Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung allergens and irritants. Exposure to these substances can lead to inflammatory responses and may induce endogenous oxidant production, which can cause ...
Cheryl van de Wetering, Evan Elko, Marijn Berg, Caspar H.J. Schiffers, Vasili Stylianidis, Maarten van den Berge, Martijn C. Nawijn, Emiel F.M. Wouters, Yvonne M.W. Janssen-Heininger, Niki L. Reynaert   +9 more
doaj   +1 more source

Early oxidation‐related changes in aqueous humor following eye exposure to ultraviolet‐A radiation

Photochemistry and Photobiology, EarlyView.
UVA exposure induces early oxidative alterations in the aqueous humor, disrupting its antioxidant balance. Levels of ascorbic acid, reduced glutathione (GSH), and the GSH/GSSG ratio decrease, while oxidized glutathione (GSSG), S‐glutathionylated proteins (PSSG), and malondialdehyde (MDA), a lipid peroxidation by‐product, increase.
Corinne Zinflou, Patrick J. Rochette
wiley   +1 more source

S-glutathionylation in cancer: from fundamental mechanisms to clinical applications

Pharmacological Research
Glutathione (GSH) is a thiol-containing antioxidant composed of glutamic acid, cysteine and glycine. GSH can form a disulfide bond with the cysteine sulfhydryl group of a protein, resulting in S-glutathionylation (-SSG).
Shuai Dong, Li Linghu, Desheng Xiao, Shuang Liu, Yongguang Tao   +4 more
doaj   +1 more source

Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model

Heliyon, 2021
Parkinson's disease is the most frequent neurodegenerative motor disorder. The clinical syndrome and pathology involve motor disturbance and the degeneration of dopaminergic neurons in the substantia nigra. Root extracts of Withania.
Jeerang Wongtrakul, Thananya Thongtan, Benjawan Kumrapich, Chonticha Saisawang, Albert J. Ketterman   +4 more
doaj   +1 more source

Ageing alters cysteine oxidation‐regulated redox signalling in skeletal muscle: Integrative omics and AI‐based structural predictions

Experimental Physiology, EarlyView.
Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins.
Venkata Ramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, Thanuja Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
doaj   +1 more source

A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

BMC Cancer, 2021
Background Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced solid tumors and ...
Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy, Douglas W. Sborov, Paul J. Shami   +17 more
doaj   +1 more source