Results 81 to 90 of about 6,885 (176)

S-glutathionylation in cancer: from fundamental mechanisms to clinical applications

Pharmacological Research
Glutathione (GSH) is a thiol-containing antioxidant composed of glutamic acid, cysteine and glycine. GSH can form a disulfide bond with the cysteine sulfhydryl group of a protein, resulting in S-glutathionylation (-SSG).
Shuai Dong, Li Linghu, Desheng Xiao, Shuang Liu, Yongguang Tao   +4 more
doaj   +1 more source

Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model

Heliyon, 2021
Parkinson's disease is the most frequent neurodegenerative motor disorder. The clinical syndrome and pathology involve motor disturbance and the degeneration of dopaminergic neurons in the substantia nigra. Root extracts of Withania.
Jeerang Wongtrakul, Thananya Thongtan, Benjawan Kumrapich, Chonticha Saisawang, Albert J. Ketterman   +4 more
doaj   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

GSH depletion, protein S-glutathionylation and mitochondrial transmembrane potential hyperpolarization are early events in initiation of cell death induced by a mixture of isothiazolinones in HL60 cells

, 2006
We recently described that brief exposure of HL60 cells to a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (CMI) and 2-methyl-4-isothiazolin-3-one (MI) induces apoptosis at low concentrations (0.001–0.01%) and necrosis at higher concentrations (0.05 ...
Frosali, Simona, Anna Di Stefano, Raffaella Priora, Anna Ettorre, Leonini, Alessandra, Priora, Raffaella, Di Simplicio, Paolo, Di Stefano, Anna, Francesca Cherubini Di Simplicio, Alessandra Leonini, Paolo Di Simplicio, Simona Frosali, Ettorre, Anna, Di Simplicio, Francesca Cherubini   +13 more
core   +1 more source

Functional Genomics of Sulfur Metabolism in Rice: Insights From Transgenic and MicroRNA‐Based Strategies

Plant Direct, Volume 10, Issue 7, July 2026.
ABSTRACT Sulfur (S) is an essential macronutrient that plays critical roles in plant growth, redox homeostasis, stress adaptation, and immunity. In rice (Oryza sativa), sulfur deficiency is becoming increasingly common due to modern agricultural practices, yet the molecular regulation of sulfur metabolism remains incompletely understood.
Fawad Rauf, Hakim Zamir, Hussam Ahmad, Daud Ali Shah, Shahrukh Khan, Zameer Hussain Jamali, Sada Tanzil, Mohammed S. Alotaibi, Usman Zulfiqar, Dilnoza Sotiboldiyeva, Dilshod Rakhmanov, Mayank Anand Gururani, Shakal Khan Korai   +12 more
wiley   +1 more source

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins.
Venkata Ramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, Thanuja Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
doaj   +1 more source

A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

BMC Cancer, 2021
Background Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced solid tumors and ...
Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy, Douglas W. Sborov, Paul J. Shami   +17 more
doaj   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding [PDF]

Cell, 2014
The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease. Titin has been identified as a target of S-glutathionylation, an end product of the nitric-oxide-signaling cascade that increases cardiac muscle elasticity.
Alegre-Cebollada, Jorge, Kosuri, Pallav, Giganti, David, Eckels, Edward, Rivas-Pardo, Jaime Andrés, Hamdani, Nazha, Warren, Chad M., Solaro, R. John, Linke, Wolfgang A., Fernández, Julio M.   +9 more
openaire   +3 more sources

Analysis of protein S-glutathionylation.

, 2013
A) Immunoblotting with anti-GSH antibody of control (lanes 1, 3) and H-RasV12 expressing cells (lanes 2, 4). Proteins (30 µg) were electrophoresed on 10% acrylamide/bis-acrylamide gel. Cell extracts were obtained either in non-reducing (lanes 1, 2) or in
Carla Emiliani (184188), Lorena Urbanelli (293124), Francesca Magherini (293125), Giovanni Principato (293128), Alessandra Modesti (293127), Alessandro Magini (184184), Armanda Pugnaloni (293126), Francesco Piva (72402), Luisa Ercolani (293123), Tatiana Armeni (293122)   +9 more
core   +1 more source