Results 41 to 50 of about 3,958,355 (265)

THROMBOPHILIA PROFILE IN YOUNG PATIENTS OF CEREBROVASCULAR ACCIDENT- AN INSTITUTION BASED STUDY

Pakistan Armed Forces Medical Journal, 2018
Objective: To find out frequency of different causes of thrombophilia in young patients of cerebrovascular accidents. Study Design: Cross sectional descriptive study.
Amna Khalid, Saleem Ahmed Khan, Nasir udin, Wasim Alamgir, Rabia Anwar, Rabia Anwar   +5 more
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Signaling beyond Punching Holes: Modulation of Cellular Responses by Vibrio cholerae Cytolysin

Toxins, 2015
Pore-forming toxins (PFTs) are a distinct class of membrane-damaging cytolytic proteins that contribute significantly towards the virulence processes employed by various pathogenic bacteria.
Barkha Khilwani, Kausik Chattopadhyay
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Dietary soy galactooligosaccharides affect the performance, intestinal function, and gut microbiota composition of growing chicks

Poultry Science, 2023
: The objective of this experiment was to investigate the effects of the dietary soy galactooligosaccharides (GOS), raffinose and stachyose, on performance, gastrointestinal health, and systemic stress in young broilers.
K.D. Teague, G. Tellez-Isaias, Jianmin Chai, V. Petrone-Garcia, C.N. Vuong, A. Blanch, S.H. Rasmussen, K. Brown, Jiangchao Zhao, S.J. Rochell   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein S and ischemic brain disease [PDF]

Vojnosanitetski Pregled, 2003
Ischemic brain disease (IBD) represents clinical entity participating with almost 80% in all vascular brain diseases. Ethiopatogenesis and pathophysiology of the ischemic brain disease are apparently most complex in human medicine.
Raičević Ranko, Jovičić Aco, Mandić-Radić Slavka, Đorđević Dragana, Marković Ljubo, Dinčić Evica   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Global within-species phylogenetics of sewage microbes suggest that local adaptation shapes geographical bacterial clustering

Communications Biology, 2023
Most investigations of geographical within-species differences are limited to focusing on a single species. Here, we investigate global differences for multiple bacterial species using a dataset of 757 metagenomics sewage samples from 101 countries ...
Marie Louise Jespersen, Patrick Munk, Joachim Johansen, Rolf Sommer Kaas, Henry Webel, Håkan Vigre, Henrik Bjørn Nielsen, Simon Rasmussen, Frank M. Aarestrup   +8 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source