Results 31 to 40 of about 2,642,890 (372)
The Carboxyl-Terminal Segment of Apolipoprotein A-V Undergoes a Lipid-Induced Conformational Change [PDF]
, 2010 Apolipoprotein (apo) A-V is a 343-residue, multidomain protein that plays an important role in regulation of plasma triglyceride homeostasis. Primary sequence analysis revealed a unique tetraproline sequence (Pro293-Pro296) near the carboxyl terminus of ...
Lee, B. L. +4 more
core +2 more sources
Cryo-EM map interpretation and protein model-building using iterative map segmentation. [PDF]
, 2020 A procedure for building protein chains into maps produced by single-particle electron cryo-microscopy (cryo-EM) is described. The procedure is similar to the way an experienced structural biologist might analyze a map, focusing first on secondary ...
Afonine PV +9 more
core +2 more sources
Predicting protein secondary structure based on ensemble Neural Network
ITEGAM-JETIA, 2021 Protein structure prediction is very vital to innovative process of discovering new medications based on the knowledge of a biological target. It is also useful for scientifically exposing the biological basis of convoluted diseases and drug effects ...
Emmanuel Gbenga Dada +3 more
doaj +1 more source
Nucleic Acids Res., 2018 Circular dichroism (CD) spectroscopy is a widely used method to study the protein secondary structure. However, for decades, the general opinion was that the correct estimation of β-sheet content is challenging because of the large spectral and ...
András Micsonai +8 more
semanticscholar +1 more source
Bayesian Segmentation of Protein Secondary Structure [PDF]
Journal of Computational Biology, 2000 We present a novel method for predicting the secondary structure of a protein from its amino acid sequence. Most existing methods predict each position in turn based on a local window of residues, sliding this window along the length of the sequence. In contrast, we develop a probabilistic model of protein sequence/structure relationships in terms of ...
S C, Schmidler, J S, Liu, D L, Brutlag
openaire +2 more sources
PCI-SS: MISO dynamic nonlinear protein secondary structure prediction
BMC Bioinformatics, 2009 Background Since the function of a protein is largely dictated by its three dimensional configuration, determining a protein's structure is of fundamental importance to biology.
Aboul-Magd Mohammed O +2 more
doaj +1 more source
A convenient protein library for spectroscopic calibrations
Computational and Structural Biotechnology Journal, 2020 While several Raman, CD or FTIR spectral libraries are available for well-characterized proteins of known structure, proteins themselves are usually very difficult to acquire, preventing a convenient calibration of new instruments and new recording ...
Joëlle De Meutter, Erik Goormaghtigh
doaj +1 more source
Protein secondary structure prediction (PSSP) using different machine algorithms
Egyptian Journal of Medical Human Genetics, 2021 Background The computational biology approach has advanced exponentially in protein secondary structure prediction (PSSP), which is vital for the pharmaceutical industry.
Heba M. Afify +3 more
doaj +1 more source
Prediction of protein secondary structure content [PDF]
Protein Engineering, Design and Selection, 1999 All existing algorithms for predicting the content of protein secondary structure elements have been based on the conventional amino-acid-composition, where no sequence coupling effects are taken into account. In this article, an algorithm was developed for predicting the content of protein secondary structure elements that was based on a new amino ...
W, Liu, K C, Chou
openaire +2 more sources
Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. [PDF]
, 2013 PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Loquet +50 more
core +3 more sources