Results 81 to 90 of about 1,631,834 (287)

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. [PDF]

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Loquet, BI Giasson, BM Fung, C Wasmer, Chad M. Rienstra, CP Jaroniec, CR Bodner, CR Morcombe, D Eliezer, DS Wishart, DS Wishart, DS Wishart, E Oldfield, EA Greenbaum, Elisa Greggio, F Delaglio, G Comellas, G Comellas, G Comellas, G Cornilescu, Gemma Comellas, H Heise, H Heise, H van Melckebeke, J Li, JJ Zarranz, Julia M. George, K Iwata, K Takegoshi, KA Conway, KD Kloepper, L Narhi, Lars K. Rikardsen, LC Serpell, LR Lemkau, Luisel R. Lemkau, M Baldus, ME van Raaij, MG Spillantini, MH Polymeropoulos, MS Celej, N Ferguson, R Bussell, R Kruger, RA Fredenburg, S Hediger, Shin W. Lee, W Choi, Wendy S. Woods, WG Hoyer, Y Shen   +50 more
core   +3 more sources

The hydration of protein secondary structures

FEBS Letters, 1987
The hydration of the main‐chain carbonyl (CO) groups in proteins have been studied using infra‐red spectroscopy, and computer‐graphics analysis of high resolution protein crystal structures. The IR measurements indicate that the strength of water binding to the CO groups is lower in β‐sheet proteins compared with α‐helical ones. Analysis of the protein
Barlow, D.J., Poole, P.L.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Secondary structure of globular proteins at the early and the final stages in protein folding [PDF]

, 1993
The ellipticities for an early transient intermediate in refolding observed by kinetic circular dichroism measurements at 220–225 nm for 14 different proteins are summarized, and the ellipticity values are compared with those for the final native ...
FINKELSTEIN Alexei V, KUWAJIMA Kunihiro, PTITSYN Oleg B, SEMISOTNOV Gennady V, SUGAI Shintaro, 邦博 桑島   +5 more
core   +2 more sources

Protein Secondary Structure Prediction

, 2008
{"references": ["Cuff, J. A. and Barton, G.J. \"Evaluation and improvement of multiple\nsequence methods for protein secondary structure prediction. Proteins,\n34, 1999, pp. 508-519.", "Cuff, J.A. and Barton G.J. \"Application of multiple sequence alignment\nprofiles to improve protein secondary structure prediction\" Proteins, 40,\n2000, pp. 502-511.",
Manpreet Singh, Sandhu, Parvinder Singh, Kaur, Reet Kamal   +2 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Improving protein fold recognition using the amalgamation of evolutionary-based and structural-based information [PDF]

, 2014
Deciphering three dimensional structure of a protein sequence is a challenging task in biological science. Protein fold recognition and protein secondary structure prediction are transitional steps in identifying the three dimensional structure of a ...
Dehzangi, A., Lyons, J., Paliwal, K.K., Sharma, Alokanand   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The development of biomolecular Raman optical activity spectroscopy [PDF]

, 2015
Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in right- and left-circularly polarized incident light or,
Barron, Laurence D.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source