Results 111 to 120 of about 418,398 (323)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Critical Features of Fragment Libraries for Protein Structure Prediction.

PLoS ONE, 2017
The use of fragment libraries is a popular approach among protein structure prediction methods and has proven to substantially improve the quality of predicted structures.
Raphael Trevizani, Fábio Lima Custódio, Karina Baptista Dos Santos, Laurent Emmanuel Dardenne   +3 more
doaj   +1 more source

Impact of residue accessible surface area on the prediction of protein secondary structures

BMC Bioinformatics, 2008
Background The problem of accurate prediction of protein secondary structure continues to be one of the challenging problems in Bioinformatics. It has been previously suggested that amino acid relative solvent accessibility (RSA) might be an effective ...
Sadeghi Mehdi, Momen-Roknabadi Amir, Pezeshk Hamid, Marashi Sayed-Amir   +3 more
doaj   +1 more source

RNA structure prediction: progress and perspective

, 2014
Many recent exciting discoveries have revealed the versatility of RNAs and their importance in a variety of cellular functions which are strongly coupled to RNA structures.
Shi, Ya-Zhou, Tan, Zhi-Jie, Wang, Feng-Hua, Wu, Yuan-Yan   +3 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Accurate prediction of protein secondary structure and solvent accessibility by consensus combiners of sequence and structure information

BMC Bioinformatics, 2007
Background Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio case but also when homology information to known structures is available ...
Vullo Alessandro, Mooney Catherine, Martin Alberto JM, Pollastri Gianluca   +3 more
doaj   +1 more source

Deep Supervised and Convolutional Generative Stochastic Network for Protein Secondary Structure Prediction [PDF]

, 2014
Jian Zhou, Olga G. Troyanskaya
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

CRNPRED: highly accurate prediction of one-dimensional protein structures by large-scale critical random networks

BMC Bioinformatics, 2006
Background One-dimensional protein structures such as secondary structures or contact numbers are useful for three-dimensional structure prediction and helpful for intuitive understanding of the sequence-structure relationship.
Kinjo Akira R, Nishikawa Ken
doaj   +1 more source

Computational identification and analysis of noncoding RNAs - Unearthing the buried treasures in the genome [PDF]

, 2007
The central dogma of molecular biology states that the genetic information flows from DNA to RNA to protein. This dogma has exerted a substantial influence on our understanding of the genetic activities in the cells.
Vaidyanathan, P. P., Yoon, Byung-Jun
core