Results 211 to 220 of about 5,630,720 (303)

A Novel 3D Model Co‐Culturing Breast Cancer Cells in Direct Contact with Patient‐Derived Mature Adipocytes Demonstrates Cell‐Type Specific Alterations in Phenotype and Chemosensitivity

Advanced Healthcare Materials, EarlyView.
A novel 3D GelMA co‐culture model enabled sustained direct contact between patient‐derived mature adipocytes and breast cancer cells, revealing subtype‐specific interactions. MDA‐MB‐231 co‐culture caused adipocyte perilipin‐1 loss and reduced chemotherapy responsiveness, while MCF7 cells showed partial epithelial‐mesenchymal transition; both cell lines
Jessika A. Wise, Margaret J. Currie, Helen R. Morrin, Gretel S. Major, Tim B. F. Woodfield, Khoon S. Lim, Elisabeth Phillips   +6 more
wiley   +1 more source

Uncleaved signal peptide drives Golgi-bypassing secretion of the baculovirus fusion protein GP64

Microbiology Spectrum
Dingxiang Zhu, Yufeng Hao, Jingsong Zhang, Ying Xu, Bifang Hao, Jinshan Huang   +5 more
doaj   +1 more source

The MFα signal sequence in yeast-based protein secretion: challenges and innovations'. [PDF]

Appl Microbiol Biotechnol
Merkaš M, Grujicic N, Geier M, Glieder A, Emmerstorfer-Augustin A.   +4 more
europepmc   +1 more source

Establishment of a Responsive Tooth‐on‐a‐Chip Platform for the Assessment of Regenerative Factors in Dental Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Using a tooth‐on‐a‐chip model that recreates interactions between dental epithelial and mesenchymal cells, the authors show that sequential FGF10+BMP4, BMP2, and Emdogain produce distinct, biologically consistent regenerative responses. The platform recapitulates known signal‐specific effects and, for the first time, reveals an influence of Emdogain on
Chong Huang, Wei Ji, Fang Yang, X. Frank Walboomers   +3 more
wiley   +1 more source

The Signal Peptidase MoSpc2 Orchestrates Fungal Development, Protein Secretion and Pathogenicity in Magnaporthe oryzae. [PDF]

Rice (N Y)
Tang W, Wang M, Bao Y, Chen W, Jiang Y, Chen M, Chen X, Yun Y, Wang Z, Chen X.   +9 more
europepmc   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng, Jianxin Li, Yuyang Luo, Yisi Liu, Feng Xing, Yingchen Ni, Fengyuan Zhang, Zhicheng Fan, Hua Xu, Weidong Zhang, Youhua Wang   +10 more
wiley   +1 more source

Exploration of endogenous signal peptides and tandem linkage strategies for enhanced heterologous protein secretion in <i>Lacticaseibacillus paracasei</i>. [PDF]

Synth Syst Biotechnol
Li X, Zhu S, Huang X, Xu Z, Guo T, Kong J, Kong W.   +6 more
europepmc   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Control of Mycobacterium tuberculosis protein secretion by ESX-4 and the outer membrane EsxUT-EsxEF complex. [PDF]

Nat Commun
Ravindran Nair R, Meikle V, Dubey S, Pavlenok M, Tischler AD, Niederweis M.   +5 more
europepmc   +1 more source

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source