Results 41 to 50 of about 6,974,231 (359)

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

Nature Communications, 2018
In mammalian cells, >25% of synthesized proteins are exported through the secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion of different proteins.
Jahir M. Gutierrez, A. Feizi, Shangzhong Li, T. B. Kallehauge, Hooman Hefzi, L. M. Grav, Daniel Ley, Deniz Baycin Hizal, M. Betenbaugh, B. Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, B. Palsson, J. Nielsen, N. Lewis   +14 more
semanticscholar   +1 more source

Protein Secretion in Spirochetes [PDF]

Microbiology Spectrum, 2019
ABSTRACT Spirochetes form a separate phylum of bacteria with two membranes but otherwise unusual morphologies and envelope structures. Distinctive common features of Borrelia , Leptospira , and Treponema include the sequestration of flagella to the periplasm ...
openaire   +2 more sources

Apolipoprotein M expression increases the size of nascent preβ HDL formed by ATP binding cassette transporter A1

Journal of Lipid Research, 2010
Apolipoprotein M (apoM) is a novel apolipoprotein that is reportedly necessary for preβ HDL formation; however, its detailed function remains unknown. We investigated the biogenesis and properties of apoM and its effects on the initial steps of nascent ...
Anny Mulya, Jeongmin Seo, Amanda L. Brown, Abraham K. Gebre, Elena Boudyguina, Gregory S. Shelness, John S. Parks   +6 more
doaj   +1 more source

Evaluation of Unconventional Protein Secretion by Saccharomyces cerevisiae and other Fungi

Cells, 2018
Development of proteome analysis of extracellular proteins has revealed that a wide variety of proteins, including fungal allergens are present outside the cell. These secreted allergens often do not contain known secretion signal sequences.
Natsuko Miura, M. Ueda
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy

Mediators of Inflammation, 2018
Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions.
Israel Cotzomi-Ortega, P. Aguilar-Alonso, J. Reyes-Leyva, P. Maycotte   +3 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Characterization and engineering of the type 3 secretion system needle monomer from Salmonella through the construction and screening of a comprehensive mutagenesis library

mSphere
Protein production strategies in bacteria are often limited due to the need for cell lysis and complicated purification schemes. To avoid these challenges, researchers have developed bacterial strains capable of secreting heterologous protein products ...
Lisa Ann Burdette, Samuel Alexander Leach, Nolan Kennedy, Bon C. Ikwuagwu, Jordan S. Summers, Danielle Tullman-Ercek   +5 more
doaj   +1 more source

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

eLife, 2022
Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery.
William J Allen, Robin A Corey, Daniel W Watkins, A Sofia F Oliveira, Kiel Hards, Gregory M Cook, Ian Collinson   +6 more
doaj   +1 more source

Protein secretion: Puzzling receptors [PDF]

Current Biology, 1998
Huttner and colleagues [1xProtein secretion: Puzzling receptors. Thiele, C, Gerdes, H-H, and Huttner, WB. Curr Biol. 1997; 7: R496–R500Abstract | Full Text | Full Text PDF | PubMedSee all References[1] have challenged the views of myself and colleagues on how prohormones are sorted to the granules of the regulated secretory pathway (RSP), at the trans ...
openaire   +2 more sources