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Protein simple sequence conservation
Proteins: Structure, Function, and Bioinformatics, 2004AbstractProtein simple sequences, a subset of low‐complexity sequences, are regions of sequence highly enriched in one or a few residue types. Simple sequences are exceedingly common, the average being more than one per protein sequence. Despite being so common, such sequences are not well‐studied.
Kim Lan, Sim, Trevor P, Creamer
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Basic Protein Sequence Analysis
Current Protocols in Molecular Biology, 2005AbstractPrediction of molecular function of proteins has become an important task in the genomics era. A wide variety of sequence analysis tools are available to biologists for this task. We have selected one or two primary protocols for tasks such as domain detection, subcellular localization, and motif detection.
Nandini, Krishnamurthy +1 more
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Gene Analysis Techniques, 1987
There has been a rapid increase in the number of available protein sequences derived from gene-sequence information. Computer-based sequence analysis of proteins is gaining in importance as an analytical tool. With the help of these analyses such sequences may be characterized and some insights gained into their probable role in the system.
D, Chatterjee, J V, Maizel
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There has been a rapid increase in the number of available protein sequences derived from gene-sequence information. Computer-based sequence analysis of proteins is gaining in importance as an analytical tool. With the help of these analyses such sequences may be characterized and some insights gained into their probable role in the system.
D, Chatterjee, J V, Maizel
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Aligning a DNA sequence with a protein sequence
Proceedings of the first annual international conference on Computational molecular biology - RECOMB '97, 1997We develop several algorithms for the problem of aligning DNA sequence with a protein sequence. Our methods account for frameshift errors, but not for introns in the DNA sequence. Thus, they are particularly appropriate for comparing a cDNA sequence that suffers from sequencing errors with an amino acid sequence or a protein sequence database.
Z, Zhang, W R, Pearson, W, Miller
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2009
Protein sequence databases do not contain just the sequence of the protein itself but also annotation that reflects our knowledge of its function and contributing residues. In this chapter, we will discuss various public protein sequence databases, with a focus on those that are generally applicable.
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Protein sequence databases do not contain just the sequence of the protein itself but also annotation that reflects our knowledge of its function and contributing residues. In this chapter, we will discuss various public protein sequence databases, with a focus on those that are generally applicable.
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High-Throughput Protein Sequencing
Analytical Chemistry, 2003We have designed and implemented an autosampler that provides additional sample capacity on a commercial protein sequencer. The autosampler attaches to a standard ABI Procise sequencer, enabling a single-sample cartridge to hold up to six separate samples. The autosampler is used in combination with faster Edman cycles and a rapid 12-min PTH separation
Victoria, Pham +4 more
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Advances in Protein Sequencing
Annual Review of Biochemistry, 1981Although this review cannot possibly cover the myriad of new ideas reported in the analyses of 1100 proteins, it does attempt to highlight procedures and strategies of interest, admittedly with a bias toward examples most familiar to us. It is clear that the scope, efficiency, and sensitivity of the analyses have increased and will continue to do so ...
K A, Walsh +3 more
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Protein Consensus Sequence Motifs
Molecular Biotechnology, 1999The large number of protein consensus sequences that may be recognized without computer analysis are reviewed. These include the extensive range of known phosphorylation site motifs for protein kinases; metal binding sites for calcium, zinc, copper, and iron; enzyme active site motifs; nucleotide binding and covalent attachment sites for prosthetic ...
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Multiple protein sequence alignment
Current Opinion in Structural Biology, 2008Multiple sequence alignments are essential in computational analysis of protein sequences and structures, with applications in structure modeling, functional site prediction, phylogenetic analysis and sequence database searching. Constructing accurate multiple alignments for divergent protein sequences remains a difficult computational task, and ...
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Protein sequence comparisons: searching databases and aligning sequences
Current Opinion in Biotechnology, 1994As the explosive growth of sequence databases continues, both the content of these databases and the best strategies for exploiting them are changing. Remarkable improvements in the performance of microcomputers have put very sophisticated tools within the reach of all investigators.
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