Results 21 to 30 of about 1,896,722 (263)

A protein structural study based on the centrality analysis of protein sequence feature networks.

PLoS ONE, 2021
In this paper, we use network approaches to analyze the relations between protein sequence features for the top hierarchical classes of CATH and SCOP. We use fundamental connectivity measures such as correlation (CR), normalized mutual information rate ...
Xiaogeng Wan, Xinying Tan
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HCMV Envelope Glycoprotein Diversity Demystified

Frontiers in Microbiology, 2019
Human cytomegalovirus (HCMV) is the leading viral cause of congenital birth defects and is responsible for morbidity and mortality in immunosuppressed individuals.
Mathilde Foglierini, Mathilde Foglierini, Jessica Marcandalli, Laurent Perez   +3 more
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Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S

STAR Protocols, 2023
Summary: Post-translational modifications (PTMs) serve as key regulatory mechanisms in various cellular processes; altered PTMs can potentially lead to human diseases.
Yu Yan, Dean Wang, Ruiqi Xin, Raine A. Soriano, Dominic C.M. Ng, Wei Wang, Peipei Ping   +6 more
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Using sound to understand protein sequence data: new sonification algorithms for protein sequences and multiple sequence alignments

BMC Bioinformatics, 2021
Background The use of sound to represent sequence data—sonification—has great potential as an alternative and complement to visual representation, exploiting features of human psychoacoustic intuitions to convey nuance more effectively.
Edward J. Martin, Thomas R. Meagher, Daniel Barker   +2 more
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Analysis of protein chameleon sequence characteristics [PDF]

Bioinformation, 2009
Conversion of local structural state of a protein from an alpha-helix to a beta-strand is usually associated with a major change in the tertiary structure. Similar changes were observed during the self assembly of amyloidogenic proteins to form fibrils, which are implicated in severe diseases conditions, e.g., Alzheimer disease. Studies have emphasized
Ghozlane, Amine, Joseph, Agnel, Bornot, Aurélie, de Brevern, Alexandre   +3 more
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Density Peak clustering of protein sequences associated to a Pfam clan reveals clear similarities and interesting differences with respect to manual family annotation

BMC Bioinformatics, 2021
Background The identification of protein families is of outstanding practical importance for in silico protein annotation and is at the basis of several bioinformatic resources.
Elena Tea Russo, Alessandro Laio, Marco Punta   +2 more
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Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

eLife, 2019
Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation and severity. This variation hampers the study of etiological differences and reduces the statistical power of analyses of associations to genetics ...
Isa Kristina Kirk, Christian Simon, Karina Banasik, Peter Christoffer Holm, Amalie Dahl Haue, Peter Bjødstrup Jensen, Lars Juhl Jensen, Cristina Leal Rodríguez, Mette Krogh Pedersen, Robert Eriksson, Henrik Ullits Andersen, Thomas Almdal, Jette Bork-Jensen, Niels Grarup, Knut Borch-Johnsen, Oluf Pedersen, Flemming Pociot, Torben Hansen, Regine Bergholdt, Peter Rossing, Søren Brunak   +20 more
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SeqCP: A sequence-based algorithm for searching circularly permuted proteins

Computational and Structural Biotechnology Journal, 2023
Circular permutation (CP) is a protein sequence rearrangement in which the amino- and carboxyl-termini of a protein can be created in different positions along the imaginary circularized sequence.
Chi-Chun Chen, Yu-Wei Huang, Hsuan-Cheng Huang, Wei-Cheng Lo, Ping-Chiang Lyu   +4 more
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Analysis of protein sequences [PDF]

Genome Biology, 2000
Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
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Coevolutionary Analysis of Protein Subfamilies by Sequence Reweighting

Entropy, 2019
Extracting structural information from sequence co-variation has become a common computational biology practice in the recent years, mainly due to the availability of large sequence alignments of protein families.
Duccio Malinverni, Alessandro Barducci
doaj   +1 more source