Results 31 to 40 of about 30,127,685 (239)

Analysis of protein sequences [PDF]

Genome Biology, 2000
Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
openaire   +1 more source

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source

Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

eLife, 2019
Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation and severity. This variation hampers the study of etiological differences and reduces the statistical power of analyses of associations to genetics ...
Isa Kristina Kirk, Christian Simon, Karina Banasik, Peter Christoffer Holm, Amalie Dahl Haue, Peter Bjødstrup Jensen, Lars Juhl Jensen, Cristina Leal Rodríguez, Mette Krogh Pedersen, Robert Eriksson, Henrik Ullits Andersen, Thomas Almdal, Jette Bork-Jensen, Niels Grarup, Knut Borch-Johnsen, Oluf Pedersen, Flemming Pociot, Torben Hansen, Regine Bergholdt, Peter Rossing, Søren Brunak   +20 more
doaj   +1 more source

Progressive search in tandem mass spectrometry

BMC Bioinformatics, 2023
Background High-throughput Proteomics has been accelerated by (tandem) mass spectrometry. However, the slow speed of mass spectra analysis prevents the analysis results from being up-to-date.
Yoonsung Joh, Kangbae Lee, Hyunwoo Kim, Heejin Park   +3 more
doaj   +1 more source

Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions (supplement).

DNA Research, 1996
The sequence determination of the entire genome of the Synechocystis sp. strain PCC6803 was completed. The total length of the genome finally confirmed was 3,573,470 bp, including the previously reported sequence of 1,003,450 bp from map position 64% to ...
T. Kaneko, Shusei Sato, H. Kotani, A. Tanaka, E. Asamizu, Yasukazu Nakamura, N. Miyajima, M. Hirosawa, M. Sugiura, S. Sasamoto, T. Kimura, T. Hosouchi, A. Matsuno, A. Muraki, N. Nakazaki, K. Naruo, S. Okumura, S. Shimpo, C. Takeuchi, T. Wada, A. Watanabe, M. Yamada, M. Yasuda, S. Tabata   +23 more
semanticscholar   +1 more source

The CATH database: an extended protein family resource for structural and functional genomics [PDF]

, 2003
The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383 superfamilies and 3285 sequence families.
Pearl, F.M.G., Martin, Nigel, Bennett, C.F., Harrison, A.P., Sillitoe, I., Shepherd, Adrian J., Thornton, Janet M., Bray, J.E., Orengo, C.A.   +8 more
core   +1 more source

Density Peak clustering of protein sequences associated to a Pfam clan reveals clear similarities and interesting differences with respect to manual family annotation

BMC Bioinformatics, 2021
Background The identification of protein families is of outstanding practical importance for in silico protein annotation and is at the basis of several bioinformatic resources.
Elena Tea Russo, Alessandro Laio, Marco Punta   +2 more
doaj   +1 more source

Real or fake? Measuring the impact of protein annotation errors on estimates of domain gain and loss events

Frontiers in Bioinformatics, 2023
Protein annotation errors can have significant consequences in a wide range of fields, ranging from protein structure and function prediction to biomedical research, drug discovery, and biotechnology.
Arnaud Kress, Olivier Poch, Odile Lecompte, Julie D. Thompson   +3 more
doaj   +1 more source

The Phyre2 web portal for protein modelling, prediction and analysis

Nature Protocols, 2015
Phyre2 is a suite of tools available on the web to predict and analyze protein structure, function and mutations. The focus of Phyre2 is to provide biologists with a simple and intuitive interface to state-of-the-art protein bioinformatics tools.
L. Kelley, S. Mezulis, C. Yates, M. Wass, M. Sternberg   +4 more
semanticscholar   +1 more source

Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]

, 2007
An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core   +1 more source