Results 41 to 50 of about 30,127,685 (239)

Coevolutionary Analysis of Protein Subfamilies by Sequence Reweighting

open access: yesEntropy, 2019
Extracting structural information from sequence co-variation has become a common computational biology practice in the recent years, mainly due to the availability of large sequence alignments of protein families.
Duccio Malinverni, Alessandro Barducci
doaj   +1 more source

Rose: Generating Sequence Families [PDF]

open access: yes, 1997
Stoye J, Evers D, Meyer F. Rose: Generating Sequence Families. Forschungsberichte.
Stoye, Jens ; https://orcid.org/   +2 more
core   +1 more source

iSeqSearch: incremental protein search for iBlast/iMMSeqs2/iDiamond [PDF]

open access: yesPeerJ
Background The advancement of sequencing technology has led to a rapid increase in the amount of DNA and protein sequence data; consequently, the size of genomic and proteomic databases is constantly growing.
Hyunwoo Yoo   +5 more
doaj   +2 more sources

BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data

open access: yesBiology Direct, 2022
Bacterial microcompartments (BMCs) are protein-based organelles found across the bacterial tree of life. They consist of a shell, made of proteins that oligomerize into hexagonally and pentagonally shaped building blocks, that surrounds enzymes ...
Markus Sutter, Cheryl A. Kerfeld
doaj   +1 more source

Computational curation and analysis of publicly available protein sequence data from a single protein family

open access: yesMethodsX, 2022
The wealth of sequence data available on public databases is increasing at an exponential rate, and while tremendous efforts are being made to make access to these resources easier, these data can be challenging for researchers to reuse because ...
Kyra Dougherty, Katalin A. Hudak
doaj   +1 more source

Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]

open access: yes, 2009
To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core   +1 more source

AlignScape, displaying sequence similarity using self-organizing maps

open access: yesFrontiers in Bioinformatics
The current richness of sequence data needs efficient methodologies to display and analyze the complexity of the information in a compact and readable manner.
Isaac Filella-Merce   +7 more
doaj   +1 more source

Principal components analysis of protein sequence clusters

open access: yesJournal of Structural and Functional Genomics, 2014
Sequence analysis of large protein families can produce sub-clusters even within the same family. In some cases, it is of interest to know precisely which amino acid position variations are most responsible for driving separation into sub-clusters.
Bo Wang, M. Kennedy
semanticscholar   +1 more source

Comprehensive analysis of sequences of a protein switch [PDF]

open access: yesProtein Science, 2015
AbstractSwitches form a special class of proteins that dramatically change their three‐dimensional structures upon a small perturbation. One possible perturbation that we explore is that of a single point mutation. Building on the pioneering experimental work of Alexander et al. (Alexander et al.
Szu-Hua, Chen   +2 more
openaire   +2 more sources

Why similar protein sequences encode similar three-dimensional structures? [PDF]

open access: yes, 2010
Evolutionarily related proteins have similar sequences. Such similarity is called homology and can be described using substitution matrices such as Blosum 60.
Zielenkiewicz, Piotr   +1 more
core   +1 more source

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