Results 51 to 60 of about 30,127,685 (239)
IEEE AccessPhosphorylation site prediction is one of the key processes in protein post-transcriptional modification. It is an important research direction in the field of bioinformatics and is of great significance for understanding protein function and signal ...
Jiale Lu, Haibin Chen, Ji Qiu
doaj +1 more source
PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments
Nucleic Acids Res., 2006 PAL2NAL is a web server that constructs a multiple codon alignment from the corresponding aligned protein sequences. Such codon alignments can be used to evaluate the type and rate of nucleotide substitutions in coding DNA for a wide range of ...
M. Suyama, D. Torrents, P. Bork
semanticscholar +1 more source
Structural analysis of Salmonella enterica effector protein SopD [PDF]
, 2004 Salmonella outer protein D (SopD) is a type III secreted virulence effector protein from Salmonella enterica. Full-length SopD and SopD lacking 16 amino acids at the N-terminus (SopDDeltaN) have been expressed as fusions with GST in Escherichia coli ...
Williams, C +7 more
core +1 more source
Filtering Degenerate Patterns with Application to Protein Sequence Analysis
Algorithms, 2013 In biology, the notion of degenerate pattern plays a central role for describing various phenomena. For example, protein active site patterns, like those contained in the PROSITE database, e.g., [FY ]DPC[LIM][ASG]C[ASG], are, in general, represented by ...
Matteo Comin, Davide Verzotto
doaj +1 more source
Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases
Cell Reports, 2021 Summary: Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease. Kinase target recognition at the active site is in part determined by a few amino acids around the phosphoacceptor residue. However, relatively little
David Bradley +5 more
doaj +1 more source
CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure [PDF]
, 2012 Background: One aim of the in silico characterization of proteins is to identify all residue-positions, which are crucial for function or structure. Several sequence-based algorithms exist, which predict functionally important sites.
Kück, Fabian +14 more
core +1 more source
Nature CommunicationsOne of the promises of precision medicine is to understand and act on inter-individual genetic differences in drug responses. SNPdrug3D contains the complete genomic landscape of missense single nucleotide variants (SNV) across the human proteome and at ...
Ashar J. Malik +37 more
doaj +1 more source
Analysis of protein-coding genetic variation in 60,706 humans
Nature, 2015 Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data ...
M. Lek +78 more
semanticscholar +1 more source
The Phylogeny of Osteopontin—Analysis of the Protein Sequence [PDF]
International Journal of Molecular Sciences, 2018 Osteopontin (OPN) is important for tissue remodeling, cellular immune responses, and calcium homeostasis in milk and urine. In pathophysiology, the biomolecule contributes to the progression of multiple cancers. Phylogenetic analysis of 202 osteopontin protein sequences identifies a core block of integrin-binding sites in the center of the protein ...
openaire +2 more sources
Species-specific analysis of protein sequence motifs using mutual information
BMC Bioinformatics, 2005 Background Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles derived from multiple sequence alignments provide an alternative description ...
Weckwerth Wolfram +3 more
doaj +1 more source