Results 81 to 90 of about 5,259,649 (407)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Combining handcrafted and learned features using deep learning to improve protein-protein interaction prediction performance

Journal of Information and Telecommunication
Understanding protein-protein interactions (PPIs) is essential because knowledge regarding PPIs helps in determining the biochemical functions of organisms. Advances made in machine learning techniques, for example, DeepFE-PPI, GcForest-PPI, and DeepPPI,
Tran Hoai Nhan, Nguyen Phuc Xuan Quynh, Le Anh Phuong   +2 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

DeepGATGO: A Hierarchical Pretraining-Based Graph-Attention Model for Automatic Protein Function Prediction [PDF]

arXiv, 2023
Automatic protein function prediction (AFP) is classified as a large-scale multi-label classification problem aimed at automating protein enrichment analysis to eliminate the current reliance on labor-intensive wet-lab methods. Currently, popular methods primarily combine protein-related information and Gene Ontology (GO) terms to generate final ...
arxiv  

Genetic Diversity and Prevalence of Porcine Circovirus Type 2 in China During 2000-2019

Frontiers in Veterinary Science, 2021
As the major pathogen for porcine circovirus-associated disease (PCVAD), porcine circovirus type 2 (PCV2) is no longer treated as an emerging virus anymore.
Ning Li, Jing Liu, Jiali Qi, Feng Hao, Lei Xu, Kangkang Guo   +5 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Distributed Many-to-Many Protein Sequence Alignment using Sparse Matrices [PDF]

arXiv, 2020
Identifying similar protein sequences is a core step in many computational biology pipelines such as detection of homologous protein sequences, generation of similarity protein graphs for downstream analysis, functional annotation and gene location.
arxiv  

Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S

STAR Protocols, 2023
Summary: Post-translational modifications (PTMs) serve as key regulatory mechanisms in various cellular processes; altered PTMs can potentially lead to human diseases.
Yu Yan, Dean Wang, Ruiqi Xin, Raine A. Soriano, Dominic C.M. Ng, Wei Wang, Peipei Ping   +6 more
doaj  

GENEUS, a computer system for DNA and protein sequence analysis containing an information retrieval system for the EMBL data library

Nucleic Acids Res., 1986
We describe a comprehensive computer system, GENEUS, for extensive DNA, RNA and protein sequence analysis. The analysis system is developed for the DEC VAX/VMS computer and uses the EMBL Nucleic Acid Sequence Data Library.
Robert Harr, Per Fällman, Mikael Häggström, Leif Wahlström, Petter Gustafsson   +4 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source