Results 1 to 10 of about 3,445,020 (250)

Kinase Targeted Anticancer Agents: A Perspective

NUST Journal of Natural Sciences, 2022
The phosphate group present in the ATP (adenosine triphosphate) is transferred to the hydroxy group-containing tyrosine, serine, or threonine residue by the protein kinases encoded in the human genome. Till now, a large number of these kinases have been
Shannelle Diana Habániková, Rubina Dad, Chandra S Azad   +2 more
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Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons

Frontiers in Cell and Developmental Biology, 2022
Group II metabotropic glutamate (mGlu) receptors (mGlu2/3) are Gαi/o-coupled receptors and are primarily located on presynaptic axonal terminals in the central nervous system.
Li-Min Mao, Nirav Mathur, Tayyibah Mahmood, Sri Rajan, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +6 more
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The function of serine/threonine-specific protein kinases in B cells

Frontiers in Immunology
The serine/threonine-specific protein kinases (STKs) are important for cell survival, proliferation, differentiation, and apoptosis. In B cells, these kinases play indispensable roles in regulating important cellular functions.
Zhennan Han, Kamel Benlagha, Pamela Lee, Chan-Sik Park, Alexander Filatov, Maria G. Byazrova, Heather Miller, Lu Yang, Chaohong Liu   +8 more
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Biology and pharmacological inhibition of homeodomain-interacting protein kinases

Frontiers in Chemical Biology
Homeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of ...
Adam Štefek, Adam Štefek, Kamil Paruch, Kamil Paruch   +3 more
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Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms

Cells
The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12 (MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage kinases, characterized by homology to serine/threonine and tyrosine kinase, but exerts ...
Kyra-Alexandra Köster, Marten Dethlefs, Jorge Duque Escobar, Elke Oetjen   +3 more
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Subcellular partitioning of protein kinase activity revealed by functional kinome profiling

Scientific Reports, 2022
Protein kinases and their substrates form signaling networks partitioned across subcellular compartments to facilitate critical biological processes. While the subcellular roles of many individual kinases have been elucidated, a comprehensive assessment ...
Lauren Wegman-Points, Khaled Alganem, Ali Sajid Imami, Victoria Mathis, Justin Fortune Creeden, Robert McCullumsmith, Li-Lian Yuan   +6 more
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A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

BMC Cancer, 2020
Background Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CCA recurrence is not well ...
Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Watcharin Loilome   +7 more
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Dynamic Protein Phosphorylation in Streptococcus pyogenes during Growth, Stationary Phase, and Starvation

Microorganisms
Phosphorylation of proteins at serine, threonine, and tyrosine residues plays an important role in physiological processes of bacteria, such as cell cycle, metabolism, virulence, dormancy, and stationary phase functions. Little is known about the targets
Stefan Mikkat, Michael Kreutzer, Nadja Patenge   +2 more
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pERK Detection Assays Using the Surefire AlphaScreen® Kit (TGR Biosciences and PerkinElmer)

Bio-Protocol, 2013
Extracellular signal-regulated kinase 1 and 2 (ERK1/2) are serine/threonine protein kinases that are phosphorylated on Thr202/Tyr204 (ERK1) and Thr185/Tyr187 (ERK2).
Cassandra Koole, Denise Wootten, Patrick Sexton   +2 more
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The regulatory impact of serine/threonine-specific protein phosphorylation among cyanobacteria

Frontiers in Plant Science
Cyanobacteria are the only prokaryotes capable of performing oxygenic photosynthesis. To thrive under environmental fluctuations, photosynthesis and metabolic activities needs to be adjusted. Previous studies showed that the acclimation of primary carbon
Thomas Barske, Martin Hagemann
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