Results 1 to 10 of about 257,816 (343)

Targeting ATM pathway for therapeutic intervention in cancer [PDF]

, 2012
The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan, Khalil, Hilal S., Lane, David P., Tummala, Hemanth, Zhelev, Nikolai   +4 more
core   +3 more sources

A Homogeneous Fluorescence Polarization Assay Adaptable for a Range of Protein Serine/Threonine and Tyrosine Kinases

Journal of biomolecular screening, 2003
Recently, a new technology for high-throughput screening has been developed, called IMAP(patent pending). IMAP technology has previously been implemented in an assay for cyclic nucleotide phosphodiesterases (PDE).
E. A. Gaudet, Kuo-Sen Huang, Yan Zhang, Wei Huang, David Mark, J. Sportsman   +5 more
semanticscholar   +1 more source

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

Molecular Brain, 2009
BackgroundThe signalling mechanisms involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) in the hippocampus are poorly understood.
S. Peineau, C. Nicolas, Z. Bortolotto, Ratan V Bhat, Jonathan Ryves, Adrian J Harwood, P. Dournaud, S. Fitzjohn, G. Collingridge   +8 more
semanticscholar   +1 more source

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L., Eales, Katherine L.   +1 more
core   +3 more sources

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]

, 2016
BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N., Hammann, P., Harashima, H., Kramer, K., Nakagami, H., Nomura, Y., Schnittger, A.   +6 more
core   +2 more sources

Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases.

Journal of Biological Chemistry, 2002
The nonreceptor Bruton's tyrosine kinase (Btk) has been previously shown to associate physically and functionally with members of the protein kinase C (PKC) family of serine/threonine kinases in a variety of cell types.
D. Crosby, A. Poole
semanticscholar   +1 more source

SGK1 in the kidney: disrupted sodium transport in diabetes and beyond [PDF]

, 2009
Renal complications of diabetes can be severe; however, the mechanisms that underlie the development and progression of diabetic nephropathy are poorly understood.
Bland, Rosemary, Hills, Claire E., Squires, Paul E.   +2 more
core  

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources

Cross-phosphorylation of bacterial serine/threonine and tyrosine protein kinases on key regulatory residues

Frontiers in Microbiology, 2014
Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the analogy might extend further, and bacterial kinases may also undergo mutual ...
Lei Shi, Nathalie Pigeonneau, Vaishnavi Ravikumar, P. Dobrinić, Boris Maček, Damjan Franjević, M. Noirot-Gros, I. Mijakovic   +7 more
semanticscholar   +1 more source

Charge environments around phosphorylation sites in proteins [PDF]

, 2008
Background: Phosphorylation is a central feature in many biological processes. Structural analyses have identified the importance of charge-charge interactions, for example mediating phosphorylation-driven allosteric change and protein binding to ...
Kitchen, James, Saunders, Rebecca E., Warwicker, Jim   +2 more
core   +2 more sources