The function of serine/threonine-specific protein kinases in B cells [PDF]
Frontiers in ImmunologyThe serine/threonine-specific protein kinases (STKs) are important for cell survival, proliferation, differentiation, and apoptosis. In B cells, these kinases play indispensable roles in regulating important cellular functions.
Zhennan Han +8 more
doaj +3 more sources
Correlated mutation analysis on the catalytic domains of serine/threonine protein kinases. [PDF]
PLoS ONE, 2009 BACKGROUND:Protein kinases (PKs) have emerged as the largest family of signaling proteins in eukaryotic cells and are involved in every aspect of cellular regulation.
Feng Xu +6 more
doaj +6 more sources
Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis. [PDF]
Frontiers in Microbiology, 2016 Bacteria possess many kinases that catalyze phosphorylation of proteins on diverse amino acids including arginine, cysteine, histidine, aspartate, serine, threonine and tyrosine.
Frédérique ePompeo +2 more
doaj +6 more sources
Mycobacterium tuberculosis Serine/Threonine Protein Kinases [PDF]
Microbiology Spectrum, 2014 The Mycobacterium tuberculosis genome encodes 11 serine/threonine protein kinases (STPKs). A similar number of two-component systems are also present, indicating that these two signal transduction mechanisms are both important in the adaptation of this ...
S. Prisic, R. Husson
semanticscholar +4 more sources
Protein serine/threonine kinases (PKA, PKC and CaMKII) involved in ischemic brain pathology
Acta Neurobiologiae Experimentalis, 1996 The protein serine/threonine kinases which are highly expressed in the central nervous system (CNS) are severely affected by brain ischemia. Irrespective of substantial differences among the particular members of this group of kinases, their responses to
Krystyna Domańska‐Janik
openalex +3 more sources
Structural basis and prediction of substrate specificity in protein serine/threonine kinases
Proceedings of the National Academy of Sciences of the United States of America, 2002 The large number of protein kinases makes it impractical to determine their specificities and substrates experimentally. Using the available crystal structures, molecular modeling, and sequence analyses of kinases and substrates, we developed a set of ...
Ross I. Brinkworth +2 more
openalex +2 more sources
Protein serine/threonine kinases (E.C. 2.7.1.-) [PDF]
Br J Pharmacol, 2009 europepmc +4 more sources
Frontiers in Microbiology, 2014 Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the analogy might extend further, and bacterial kinases may also undergo mutual ...
Lei eShi +7 more
doaj +2 more sources
Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro. [PDF]
Molecular and Cellular Biology, 1991 Protein kinase assays that use recombinant pp90rsk as a substrate were developed in an attempt to identify growth-regulated enzymes responsible for the phosphorylation and activation of pp90rsk S6 phosphotransferase activity.
Jongkyeong Chung +2 more
openalex +2 more sources
Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 [PDF]
The EMBO Journal, 1997 Mitogen‐activated protein (MAP) kinases bind tightly to many of their physiologically relevant substrates. We have identified a new subfamily of murine serine/threonine kinases, whose members, MAP kinase‐interacting kinase 1 (Mnk1) and Mnk2, bind tightly
A. Waskiewicz +3 more
semanticscholar +4 more sources