Results 171 to 180 of about 261,891 (384)

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

The pim‐1 oncogene encodes two related protein‐serine/threonine kinases by alternative initiation at AUG and CUG.

EMBO Journal, 1991
C. Saris, J. Domen, A. Berns
semanticscholar   +1 more source

Deduced Primary Structure of the β Subunit of Brain Type II Ca2+/calmodulin-dependent Protein Kinase Determined by Molecular Cloning [PDF]

, 1987
cDNA clones coding for the β subunit of rat brain type II Ca2+/calmodulin-dependent protein kinase were isolated and sequenced. The clones, including one containing the entire coding region, hybridize at high stringency to a single band of poly(A)+ RNA ...
Bennett, Mark K., Kennedy, Mary B.
core  

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors

Cells
Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer.
Mohammed Hawash
doaj   +1 more source

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

, 1987
L. Bryan Ray, T W Sturgill
openalex   +1 more source

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo [PDF]

, 2000
Sean P. COLLINS, Junewai L. REOMA, David M. GAMM, Michael D. UHLER   +3 more
openalex   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

, 1990
John Kyriakis, Joseph Avruch
openalex   +1 more source

TheMycobacterium bovishomologous protein of theMycobacterium tuberculosisserine/threonine protein kinase Mbk (PknD) is truncated [PDF]

, 2000
Priska Peirs, B. Parmentier, Luk De Wit, J. Content   +3 more
openalex   +1 more source