Results 201 to 210 of about 212,467 (329)

Correction: Correlated Mutation Analysis on the Catalytic Domains of Serine/Threonine Protein Kinases

PLoS ONE, 2009
Feng Xu, Pan Du, Hongbo Shen, Hairong Hu, Qi Wu, Jun Xie, Long Yu   +6 more
doaj   +3 more sources

The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]

, 2011
Sapkota, Gopal P., Traynor, Ryan, Vogt, Janis   +2 more
core   +2 more sources

The link of FOXO1 and FOXO4 transcription factors to development of the lens

Developmental Dynamics, EarlyView.
Abstract Background The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens.
Rifah N. Gheyas, Ruby C. Williams, Kelly A. Ryan, A. Sue Menko   +3 more
wiley   +1 more source

Targeting NEK Kinases in Gastrointestinal Cancers: Insights into Gene Expression, Function, and Inhibitors. [PDF]

Int J Mol Sci
Chen L, Lu H, Ballout F, El-Rifai W, Chen Z, Gokulan RC, McDonald OG, Peng D.   +7 more
europepmc   +1 more source

Discovering new hub genes of dilated cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
wiley   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Targeting kinases that regulate programmed cell death: a new therapeutic strategy for breast cancer. [PDF]

J Transl Med
Hong Y, He J, Deng D, Liu Q, Zu X, Shen Y.   +5 more
europepmc   +1 more source

Global landscape of protein phosphorylation during plant regeneration initiation in cotton (Gossypium hirsutum L.). [PDF]

BMC Biol
Guo H, Qi X, Zhang L, Guo H, Gao F, Tian X, Wu J, Li T, Yan T, Cui X, Xu J, Zeng F.   +11 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

<i>O</i>-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies. [PDF]

Int J Mol Sci
Bolanle IO, Palmer TM.
europepmc   +1 more source