Results 211 to 220 of about 142,067 (264)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Characterization of Mast2 kinase defines structural features, regulation, and substrates. [PDF]

J Biol Chem
Lemke MC, Chen M, Jang SS, Rader MT, Avala NR, Bauchle CJ, Pluguez R, Miller CJ, Butler JD, Hargett SR, Lank DS, Seltzer BD, Stornetta DS, Fu Z, Hsu KL, Harris TE.   +15 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Dexpanthenol mitigates trauma-induced lung injury by modulating RIPK1/RIPK3/MLKL-mediated necroptosis in rats. [PDF]

Sci Rep
Camas HE, Savran M, Akin SE, Dongel I, Yazkan R, Yildirim HE, Ilhan I, Tepebasi MY, Sevuk MA, Ozmen O.   +9 more
europepmc   +1 more source

Integrated Expression Analysis May Support Serine/Threonine Kinases as Common Hub Genes in Breast Cancer. [PDF]

Iran J Med Sci
Ekhtiyari MS, Ghaderi-Zefrehei M, Mogharari Z, Yousefi M, Bigdeli A, Nasre Esfahani E, Shahriarpour H, Leschm BJ.   +7 more
europepmc   +1 more source

Comprehensive Analysis of the Putative Substratome of FAM20C, the Master Serine Kinase of the Secretory Pathway. [PDF]

Biomolecules
Cesaro L, Noventa F, De Los Angeles Cordero T, Molon B, Bosello Travain V, Aspromonte MC, Salvi M.   +6 more
europepmc   +1 more source

Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies. [PDF]

Cell Oncol (Dordr)
Liu N, van der Ende F, van de Water B, Le Dévédec SE.   +3 more
europepmc   +1 more source

Emerging role of DYRK1A as a target in cardiovascular diseases (Review). [PDF]

Mol Med Rep
Yu L, Cheng Q, Wu J.
europepmc   +1 more source

Let the peptides shine: SOX (Sulfonamido-OXine)-labelled peptides for direct kinase and phosphatase monitoring. [PDF]

RSC Chem Biol
Papagora LE, Cochrane SA.
europepmc   +1 more source