Results 211 to 220 of about 3,595,860 (302)

Phosphosite-specific co-regulation networks of MELK kinase: insights from integrative global phosphoproteomes. [PDF]

open access: yesJ Genet Eng Biotechnol
Khan NA   +7 more
europepmc   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

open access: yesAllergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan   +5 more
wiley   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

open access: yesBrain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom   +7 more
wiley   +1 more source

DYRK kinases phosphorylate IL-17RA at S801. [PDF]

open access: yesSerican J Med
Moududee SA   +4 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Structural insights into multitargeting <i>Mycobacterium tuberculosis</i> Pkn kinases. [PDF]

open access: yesMicrobiol Spectr
Pölläniemi A   +6 more
europepmc   +1 more source

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