Results 231 to 240 of about 212,255 (348)

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

The expression of tyrosine kinase and threonine promotes the progression of lung adenocarcinoma and is linked to a negative prognosis. [PDF]

Medicine (Baltimore)
Zhu X, Li S, Ye L, Ye L.
europepmc   +1 more source

Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL of Corynebacterium glutamicum: evidence for non‐essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases [PDF]

, 2009
Christian Schultz, Axel Niebisch, Astrid Schwaiger, Ulrike Viets, Sabine Metzger, Marc Bramkamp, Michael Bott   +6 more
openalex   +1 more source

Serine/Threonine-Protein Kinase Nek10 [PDF]

, 2020
openaire   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Early Development of Ocadusertib, a Selective Receptor-Interacting Serine/Threonine-Protein Kinase 1 Inhibitor. [PDF]

Clin Transl Sci
Shaw SJ, Taylor VC, Sims JT, Ho S, Lamagna C, Yan L, Reising NC, Chow A, Hanson EP, Vendel AC, Dairaghi DJ, Masuda ES.   +11 more
europepmc   +1 more source

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice [PDF]

, 1996
Osamu Nakagawa, Kazuko Fujisawa, Toshimasa Ishizaki, Yuji Saito, Kazuwa Nakao, Shuh Narumiya   +5 more
openalex   +1 more source

A point mutation in the putative ATP binding site of the pseudorabies virus US3 protein kinase prevents Bad phosphorylation and cell survival following apoptosis induction [PDF]

, 2007
Deruelle, Matthias, Favoreel, Herman, Geenen, Kristin, Nauwynck, Hans   +3 more
core   +2 more sources

Serine/Threonine-Protein Kinase Nek9 [PDF]

, 2020
openaire   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source