Results 221 to 230 of about 212,467 (329)

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, EarlyView.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source

Histone Phosphorylation in DNA Damage Response. [PDF]

Int J Mol Sci
Gong P, Guo Z, Wang S, Gao S, Cao Q.
europepmc   +1 more source

Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients

International Journal of Cancer, EarlyView.
What's New? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini, Luciano Calzari, Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Mila Ravegnani, Valentina Arcangeli, Alessandro Passardi, Elisabetta Petracci, Sara Bravaccini, Giorgia Marisi, Alessandra Viel, Daniela Barana, Monica Pedroni, Luca Roncucci, Daniele Calistri, Davide Gentilini   +18 more
wiley   +1 more source

Positional distribution and conservation of major phosphorylated sites in the human kinome. [PDF]

Front Mol Biosci
Gopalakrishnan AP, Shivamurthy PB, Ahmed M, Ummar S, Ramesh P, Thomas SD, Mahin A, Nisar M, Soman S, Subbannayya Y, Raju R.   +10 more
europepmc   +1 more source

Underlying Mechanism of Jiuwei Shengmai Powder in Improving Myocardial Hypoxia at High Altitude Based on Network Pharmacology and Molecular Docking

iLABMED, EarlyView.
The expression pathway of COX and the downstream mechanism of PGE. M: muscarinic receptor; PL: phospholipid; PLA2: phospholipase A2; AA: arachidonic acid; EP1: prostaglandin E1 receptor; EP2: prostaglandin E2 receptor; EP3: prostaglandin E3 receptor; EP4: prostaglandin E4 receptor.
Cong Wu, Yanjuan Zhu, Changpeng Xie, Haobo Liu, Yuanming Pan, Chang'e Liu   +5 more
wiley   +1 more source

Dissection of genetic basis underlying heat stress response of Apis cerana. [PDF]

BMC Genomics
Li AM, Pang CX, Cai XL, Zhuo FC, Hu B, Huang XH, Huang JX, Lu YM.   +7 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Type One Protein Phosphatase 4aD Negatively Regulates Cotton (<i>Gossypium hirsutum</i>) Salt Tolerance by Inhibiting the Phosphorylation of Kinases That Respond to Abscisic Acid. [PDF]

Int J Mol Sci
Cao P, Zhao M, Liu J, Du M, Tian X, Li F, Li Z.   +6 more
europepmc   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

Insulin receptor responsiveness governs TGFβ-induced hepatic stellate cell activation: Insulin resistance instigates liver fibrosis. [PDF]

FASEB J
Lee WH, Bates EA, Kipp ZA, Pauss SN, Martinez GJ, Blair CA, Hinds TD.   +6 more
europepmc   +1 more source