Results 231 to 240 of about 209,848 (307)
British Journal of Haematology, EarlyView.Summary Mature T‐cell lymphomas comprise a heterogeneous group of aggressive non‐Hodgkin lymphomas with limited therapeutic options in the relapsed or refractory setting. Among them, anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma (ALCL) represents a biologically distinct subtype driven by constitutive activation of ALK fusion ...
Santino Caserta +13 more
wiley +1 more source
Novel <i>SZT2::MAST2</i> Fusion Detected in Salivary Duct Carcinoma. [PDF]
Case Rep PatholBedeir A +4 more
europepmc +1 more source
Targeting BRAF in cancers - from molecular diagnostics to personalized therapy. [PDF]
BioTechnologia (Pozn)Pyc Z +4 more
europepmc +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Molecular docking and dynamics in protein serine/threonine kinase drug discovery: advances, challenges, and future perspectives. [PDF]
Front PharmacolHasan GM +4 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz +8 more
wiley +1 more source
TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PDF]
AutophagyMordes DA, Smeyers J.
europepmc +1 more source