Results 61 to 70 of about 1,785,938 (267)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Digestibility and palatability of isolated porcine protein in dogs

Italian Journal of Animal Science, 2018
The objective of this study was to evaluate the digestibility and palatability of an isolated porcine protein (IPP) for adult dogs. In the digestibility assay, eight adult Beagle dogs were distributed in a double Latin square (4 × 4) experimental design.
Fabiane Yukiko Murakami, Daniele Cristina de Lima, Camilla Mariane Menezes Souza, Gislaine Bill Kaele, Simone Gisele de Oliveira, Ananda Portella Félix   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology

Journal of Cheminformatics
Current strategies centred on either merging or linking initial hits from fragment-based drug design (FBDD) crystallographic screens generally do not fully leaverage 3D structural information.
Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Desempenho e composição dos filés de jundiás (Rhamdia quelen) submetidos a diferentes dietas na fase de recria Performance and fillet composition of jundiá (Rhamdia quelen) submitted to different diets in the rearing

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2008
Avaliaram-se o crescimento e a composição dos filés de juvenis de jundiá após 90 dias de alimentação com dietas contendo diferentes fontes protéicas. Foram utilizados 540 peixes, peso inicial=15,0±0,62g; comprimento inicial=11,98±0,35cm, distribuídos ao ...
R. Lazzari, J. Radünz Neto, F.A. Pedron, C.A. Veiverberg, G.T. Bergamin, R.L. Lima, T. Emanuelli, C. Steffens   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

ILEAL DIGESTIBILITY OF AMINO ACIDS IN PIG FEEDS AND ITS USE IN DIET FORMULATIONS [PDF]

Poljoprivreda, 2000
The effects of four protein sources (soybean meal, sunflower meal, pea and fish meal as the main protein source) were investigated on fattening performance, carcass and meat quality traits and body composition of pigs.
Cszaba Szabo, Laszlo Babinszky, A.J.M. Jansman, E. Kanis, M.W.A. Verstegen   +4 more
doaj