Results 1 to 10 of about 3,840,867 (319)
Scientific Reports, 2022 Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that regulates endosomal trafficking in eukaryotic cells. Recent studies have shown that VPS35 promotes tumor cell proliferation and affects the nuclear accumulation of its ...
Xian Hong +9 more
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BMC Cancer, 2021 Background Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extracellular compartment in multiple ...
Xian Hong +9 more
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Structure of human TRPM8 channel
Communications Biology, 2023 TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer drug development,
Sergii Palchevskyi +7 more
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Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Nature Communications, 2023 Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu +10 more
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Curvature sensing of curvature-inducing proteins with internal structure [PDF]
Phys. Rev. E 109, 024403 (2024), 2023 Many types of peripheral and transmembrane proteins can sense and generate membrane curvature. Laterally isotropic proteins and crescent proteins with twofold rotational symmetry, such as Bin/Amphiphysin/Rvs superfamily proteins, have been studied theoretically. However, proteins often have an asymmetric structure or a higher rotational symmetry.
arxiv +1 more source
Inorganics, 2020 [Fe]-hydrogenase (Hmd) catalyzes the reversible heterolytic cleavage of H2, and hydride transfer to methenyl-tetrahydromethanopterin (methenyl-H4MPT+).
Gangfeng Huang +3 more
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Cancer Nanotechnology, 2023 Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Rebekah Anamarie Gundersen +10 more
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Biophysical characterization of a protein for structure comparison : methods for identifying insulin structural changes [PDF]
, 2016 Although protein structure has been studied for many decades it remains the case that we cannot state with confidence whether two samples have the same molecular structure, particularly in solution.
Blindauer, Claudia A. +5 more
core +1 more source
Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560
Nature Communications, 2022 Presenilin isoforms (PS1 and PS2) containing γ-secretase show contrasting sensitivity to MRK-560. Here, the authors determined cryo-EM structures of PS1/PS2-complexes treated with MRK-560 and identified key residues responsible for the isoform-dependent ...
Xuefei Guo +10 more
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PON-SC – program for identifying steric clashes caused by amino acid substitutions
BMC Bioinformatics, 2017 Background Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites.
Jelena Čalyševa, Mauno Vihinen
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