Results 1 to 10 of about 2,069,772 (318)
Scientific Reports, 2022 Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that regulates endosomal trafficking in eukaryotic cells. Recent studies have shown that VPS35 promotes tumor cell proliferation and affects the nuclear accumulation of its ...
Xian Hong +9 more
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BMC Cancer, 2021 Background Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extracellular compartment in multiple ...
Xian Hong +9 more
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WASH interacts with Ku to regulate DNA double-stranded break repair
iScience, 2022 Summary: The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH), an actin nucleation-promoting factor, is present in the nucleus where it regulates gene transcription and maintains nuclear organization.
Tao Wang +9 more
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Structure of human TRPM8 channel
Communications Biology, 2023 TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer drug development,
Sergii Palchevskyi +7 more
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Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Nature Communications, 2023 Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu +10 more
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Inorganics, 2020 [Fe]-hydrogenase (Hmd) catalyzes the reversible heterolytic cleavage of H2, and hydride transfer to methenyl-tetrahydromethanopterin (methenyl-H4MPT+).
Gangfeng Huang +3 more
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Cancer Nanotechnology, 2023 Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Rebekah Anamarie Gundersen +10 more
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Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560
Nature Communications, 2022 Presenilin isoforms (PS1 and PS2) containing γ-secretase show contrasting sensitivity to MRK-560. Here, the authors determined cryo-EM structures of PS1/PS2-complexes treated with MRK-560 and identified key residues responsible for the isoform-dependent ...
Xuefei Guo +10 more
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Molecular basis for protein histidine N1-specific methylation of the “His-x-His” motifs by METTL9
Cell Insight, 2023 Histidine methylation serves as an intriguing strategy to introduce altered traits of target proteins, including metal ion chelation, histidine-based catalysis, molecular assembly, and translation regulation.
Wentao Zhao +6 more
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PON-SC – program for identifying steric clashes caused by amino acid substitutions
BMC Bioinformatics, 2017 Background Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites.
Jelena Čalyševa, Mauno Vihinen
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