Results 51 to 60 of about 1,631,863 (295)

Why Do Proteins Look Like Proteins?

, 1996
Protein structures in nature often exhibit a high degree of regularity (secondary structures, tertiary symmetries, etc.) absent in random compact conformations.
Helling, Robert, Li, Hao, Tang, Chao, Wingreen, Ned   +3 more
core   +1 more source

Thermal stability and aggregation of sulfolobus solfataricus b-glycosidase are dependent upon the N-e-methylation of specific lysyl residues: critical role of in vivo post-translational modifications. [PDF]

, 2004
Methylation in vivo is a post-translational modification observed in several organisms belonging to eucarya, bacteria, and archaea. Although important implications of this modification have been demonstrated in several eucaryotes, its biological role in ...
A. ANDOLFO, A. SCIRE, C. VACCARO, E. BERTOLI, F. FEBBRAIO, F. GENTILE, F. TANFANI, PUCCI, PIETRO, R. BRIANTE, R. N.U.C.C.I., S. FORMISANO   +10 more
core   +1 more source

Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill, Ansari AA, Atvinder K. Rullay, Bertozzi CR, Blanch EW, Borchelt D, Caughey B, Caughey B, Caughey B, Caughey BW, Critchley P, David H. Crout, Eberl H, Ferris A, Georges C, Gill AC, Govaerts C, Haire LF, Harris DA, Hornemann S, Ian D. Sylvester, Imanpreet K. Bath, Kazlauskaite J, Kazlauskaite J, Kenyon GL, King SA, Kirby L, Klein TR, Kocienski PJ, Legname G, Matthew R. Hicks, Mui B, Nosjean O, Pan KM, Poss AJ, Safar J, Seddon AM, Shyng SL, Stahl N, Stahl N, Teresa J. T. Pinheiro, Whitesell JK, Wuthrich K, Zahn R, Zhang ZY   +44 more
core   +1 more source

Improved probability graph model for protein secondary structure prediction

Journal of Hebei University of Science and Technology, 2016
Protein secondary structure is closely related to protein tertiary structure and function, and became a hot topic in bioinformatics. The probability graph model HMM (Hidden Markov model) is an important tool in this field.
Lingqi ZHAO, Lijuan ZHU, Kejing WANG, Xiaoqing DONG, Yi ZHANG   +4 more
doaj   +1 more source

BCL::Score--knowledge based energy potentials for ranking protein models represented by idealized secondary structure elements. [PDF]

PLoS ONE, 2012
The topology of most experimentally determined protein domains is defined by the relative arrangement of secondary structure elements, i.e. α-helices and β-strands, which make up 50-70% of the sequence.
Nils Woetzel, Mert Karakaş, Rene Staritzbichler, Ralf Müller, Brian E Weiner, Jens Meiler   +5 more
doaj   +1 more source

Protein Secondary Structure Prediction

International Journal of Innovative Technology and Exploring Engineering, 2019
Proteins are made up of basic units called amino acids which are held together by bonds namely hydrogen and ionic bond. The way in which the amino acids are sequenced has been categorized into two dimensional and three dimensional structures. The main advantage of predicting secondary structure is to produce tertiary structure likelihoods that are in ...
Priyanka B V, Rachitha K T, Sanchitha N, Srinidhi H S, Pavankumar S P, Shashank N   +5 more
openaire   +1 more source

Protein secondary structure prediction in different structural classes [PDF]

Protein Engineering Design and Selection, 1998
Information about the secondary structure of a protein can be helpful in understanding its native folded state. In previous work, it was shown that the medium-range interactions predominate in all-alpha class and the long-range interactions predominate in all-beta class proteins.
M M, Gromiha, S, Selvaraj
openaire   +2 more sources

Identification of a protein encoded in the EB-viral open reading frame BMRF2 [PDF]

, 1992
Using monospecific rabbit sera against a peptide derived from a potential antigenic region of the Epstein-Barr viral amino acid sequence encoded in the open reading frame BMRF2 we could identify a protein-complex of 53/55 kDa in chemically induced B95-8,
A. v. Brunn, B Böttinger, E Tschachler, G Myers, GJ Clements, GJ LaRosa, H Takahashi, H Takahashi, H Takahashi, H. Fließbach, H. Wolf, HK Lyerly, HK Lyerly, J Goudsmit, J Goudsmit, JE Gregersen, K Javaherian, K Javaherian, LA Lasky, M Clerici, M Clerici, M. Niedrig, NL Haigwood, P Simmonds, PJ Durda, PW Berman, R Wagner, R. Wagner, RA Neurath, RH Meloen, S Modrow, S Modrow, SD Putney, Susanne Modrow, T Hattori, TJ Palker, Traudel Böltz, Y Devash   +37 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Multistage Combination Classifier Augmented Model for Protein Secondary Structure Prediction

Frontiers in Genetics, 2022
In the field of bioinformatics, understanding protein secondary structure is very important for exploring diseases and finding new treatments. Considering that the physical experiment-based protein secondary structure prediction methods are time ...
Xu Zhang, Yiwei Liu, Yaming Wang, Liang Zhang, Lin Feng, Bo Jin, Hongzhe Zhang   +6 more
doaj   +1 more source