Results 31 to 40 of about 319,877 (305)

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-Synuclein within E. coli cells [PDF]

, 2013
α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein ...
A Binolfi, Anthony W. P. Fitzpatrick, AS Maltsev, AS Morar, B Fauvet, B Fauvet, BC McNulty, C Camilloni, C Huang, C Lendel, C Li, C Li, CA Waudby, CA Waudby, Carlo Camilloni, Christopher A. Waudby, Christopher M. Dobson, CO Barnes, CR Bodner, CW Bertoncini, D Eliezer, D Sakakibara, DS Biggs, DS Burz, DS Wishart, DS Wishart, E Lescop, EJ De Genst, F Chiti, F Delaglio, F Ferrage, I Bertini, IR Booth, John Christodoulou, JR Allison, K Inomata, KM Slade, KR Metz, Lisa D. Cabrita, Michele Vendruscolo, MM Dedmon, MR Cookson, P Bernadó, P Sarder, P Schanda, PH Weinreb, Piero Andrea Temussi, RC Puetter, SF Gull, T Bartels, TS Ulmer, VN Uversky, VN Uversky, W Wang, WF Vranken, WS Davidson, Z Serber, Z Serber   +57 more
core   +5 more sources

Modeling the Tertiary Structure of the Rift Valley Fever Virus L Protein

Molecules, 2019
A tertiary structure governs, to a great extent, the biological activity of a protein in the living cell and is consequently a central focus of numerous studies aiming to shed light on cellular processes central to human health. Here, we aim to elucidate
Gideon K. Gogovi, Fahad Almsned, Nicole Bracci, Kylene Kehn-Hall, Amarda Shehu, Estela Blaisten-Barojas   +5 more
doaj   +1 more source

A systematic structural comparison of all solved small proteins deposited in PDB. The effect of disulfide bonds in protein fold

Computational and Structural Biotechnology Journal, 2021
Defensins are small proteins, usually ranging from 3 to 6 kDa, amphipathic, disulfide-rich, and with a small or even absent hydrophobic core. Since a hydrophobic core is generally found in globular proteins that fold in an aqueous solvent, the peculiar ...
Mariana H. Moreira, Fabio C.L. Almeida, Tatiana Domitrovic, Fernando L. Palhano   +3 more
doaj   +1 more source

Crystal structure of domain of unknown function 507 (DUF507) reveals a new protein fold

Scientific Reports, 2023
The crystal structure of the domain of unknown function family 507 protein from Aquifex aeolicus is reported (AaDUF507, UniProt O67633, 183 residues). The structure was determined in two space groups (C2221 and P3221) at 1.9 Å resolution.
Cole E. McKay, Jianlin Cheng, John J. Tanner   +2 more
doaj   +1 more source

NMR solution structure of a chymotrypsin inhibitor from the Taiwan cobra Naja naja atra [PDF]

, 2013
The Taiwan cobra (Naja naja atra) chymotrypsin inhibitor (NACI) consists of 57 amino acids and is related to other Kunitz-type inhibitors such as bovine pancreatic trypsin inhibitor (BPTI) and Bungarus fasciatus fraction IX (BF9), another chymotrypsin ...
Chang, Long-Sen, Güntert, Peter, Ikeya, Teppei, Lin, Yi-Jan   +3 more
core   +2 more sources

Protein Tertiary Structure by Crosslinking/Mass Spectrometry [PDF]

Trends in Biochemical Sciences, 2018
Observing the structures of proteins within the cell and tracking structural changes under different cellular conditions are the ultimate challenges for structural biology. This, however, requires an experimental technique that can generate sufficient data for structure determination and is applicable in the native environment of proteins. Crosslinking/
Michael Schneider, Adam Belsom, Juri Rappsilber   +2 more
openaire   +3 more sources

Why Do Proteins Look Like Proteins?

, 1996
Protein structures in nature often exhibit a high degree of regularity (secondary structures, tertiary symmetries, etc.) absent in random compact conformations.
Helling, Robert, Li, Hao, Tang, Chao, Wingreen, Ned   +3 more
core   +1 more source

Stabilisation of Na,K-ATPase structure by the cardiotonic steroid ouabain [PDF]

, 2013
Cardiotonic steroids such as ouabain bind with high affinity to the membrane-bound cation-transporting P-type Na,K-ATPase, leading to complete inhibition of the enzyme.
Abdul-Gader, Andrew J. Miles, B.A. Wallace, Esmann, Esmann, Esmann, Esmann, Fedosova, Kabsch, Kaplan, Klodos, Klose, Lees, Lowry, Mikael Esmann, Miles, Miles, Miles, Miles, Morth, Natalya U. Fedosova, Ogawa, Provencher, Schoner, Shinoda, Skou, Sreerama, Søren V. Hoffmann, Van Stokkum, Whitmore, Yatime   +30 more
core   +1 more source

Photoreceptors for a light biotransducer: a comparative study of the electrical responses of two (type-1)-opsins

, 2013
The increasing interest in photoactivated proteins as natural replacement of standard inorganic materials in photocells drives to the compared analysis of bacteriorhodopsin and proteorhodopsin, two widely diffused proteins belonging to the family of ...
Alfinito, E, Lee, K, Pousset, J, Reggiani, L   +3 more
core   +1 more source

PROTINFO: secondary and tertiary protein structure prediction [PDF]

Nucleic Acids Research, 2003
Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling ...
Ling-Hong, Hung, Ram, Samudrala
openaire   +2 more sources