Results 61 to 70 of about 319,877 (305)

Statistical analysis of protein molecules [PDF]

, 2011
In this paper, entropy and auto-correlation values of main chain dihedral angles of 22,356 protein molecules are calculated and found to lie within a well-specified range for most proteins.
Kushal Shah
core   +1 more source

Tertiary Structure of Uracil-DNA Glycosylase Inhibitor Protein [PDF]

Journal of Biological Chemistry, 1995
The Bacillus subtilis bacteriophage PBS2 uracil-DNA glycosylase inhibitor (Ugi) is an acidic protein of 84 amino acids that inactivates uracil-DNA glycosylase from diverse organisms. The secondary structure of Ugi consists of five anti-parallel beta-strands and two alpha-helices (Balasubramanian, S., Beger, R.D., Bennett, S.E., Mosbaugh, D.W., and ...
R D, Beger, S, Balasubramanian, S E, Bennett, D W, Mosbaugh, P H, Bolton   +4 more
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

A triphosphate tunnel metalloenzyme from pear (PbrTTM1) moonlights as an adenylate cyclase

Frontiers in Plant Science, 2023
Adenylyl cyclase (AC) is the vital enzyme for generating 3′,5′-cyclic adenosine monophosphate, an important signaling molecule with profound nutritional and medicinal values.
Ye Yuan, Yuye Liu, Shuangjiang Chen, Lili Wang, Lili Wang, Lixin Wang, Lixin Wang, Yahong Niu, Xin Zhao, Zhihui Zhao, Zhihui Zhao, Zhiguo Liu, Zhiguo Liu, Mengjun Liu, Mengjun Liu   +14 more
doaj   +1 more source

Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. [PDF]

, 2016
The intrinsic apoptosis pathway occurs through the release of mitochondrial cytochrome c to the cytosol, where it promotes activation of the caspase family of proteases.
Christian, Thomas, Hou, Ya-Ming, Liu, Cuiping, Stonestrom, Aaron J, Takase, Ryuichi, Yang, Xiaolu, Yong, Jeongsik   +6 more
core   +2 more sources

Tertiary alphabet for the observable protein structural universe [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Proteins fold into intricate 3D structures, determined by their amino acid sequences. Different proteins can fold into drastically different structures, and the space of all possible structures appears hopelessly complex.
Craig O, Mackenzie, Jianfu, Zhou, Gevorg, Grigoryan   +2 more
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Coupled prediction of protein secondary and tertiary structure [PDF]

Proceedings of the National Academy of Sciences, 2003
The strong coupling between secondary and tertiary structure formation in protein folding is neglected in most structure prediction methods. In this work we investigate the extent to which nonlocal interactions in predicted tertiary structures can be used to improve secondary structure prediction.
Jens, Meiler, David, Baker
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A hybrid variational autoencoder and WGAN with gradient penalty for tertiary protein structure generation

Scientific Reports
Elucidating the tertiary structure of proteins is important for understanding their functions and interactions. While deep neural networks have advanced the prediction of a protein’s native structure from its amino acid sequence, the focus on a single ...
Aalaa I. Sehsah, Afaf Mousa, Gamal Farouk   +2 more
doaj   +1 more source