Results 11 to 20 of about 19,302,461 (314)
WASH interacts with Ku to regulate DNA double-stranded break repair
iScience, 2022 Summary: The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH), an actin nucleation-promoting factor, is present in the nucleus where it regulates gene transcription and maintains nuclear organization.
Tao Wang +9 more
doaj +1 more source
Before and after AlphaFold2: An overview of protein structure prediction
Frontiers in Bioinformatics, 2023 Three-dimensional protein structure is directly correlated with its function and its determination is critical to understanding biological processes and addressing human health and life science problems in general.
Letícia M. F. Bertoline +3 more
semanticscholar +1 more source
Comparative Protein Structure Modeling Using MODELLER
Current Protocols in Bioinformatics, 2016 Comparative protein structure modeling predicts the three‐dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates).
Ben M. Webb, A. Sali
semanticscholar +2 more sources
Critical assessment of methods of protein structure prediction (CASP)—Round XIV
Proteins: Structure, Function, and Bioinformatics, 2021 Critical assessment of structure prediction (CASP) is a community experiment to advance methods of computing three‐dimensional protein structure from amino acid sequence. Core components are rigorous blind testing of methods and evaluation of the results
A. Kryshtafovych +4 more
semanticscholar +1 more source
Structure of human TRPM8 channel
Communications Biology, 2023 TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer drug development,
Sergii Palchevskyi +7 more
doaj +1 more source
Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Nature Communications, 2023 Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu +10 more
doaj +1 more source
Inorganics, 2020 [Fe]-hydrogenase (Hmd) catalyzes the reversible heterolytic cleavage of H2, and hydride transfer to methenyl-tetrahydromethanopterin (methenyl-H4MPT+).
Gangfeng Huang +3 more
doaj +1 more source
Cancer Nanotechnology, 2023 Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Rebekah Anamarie Gundersen +10 more
doaj +1 more source
Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560
Nature Communications, 2022 Presenilin isoforms (PS1 and PS2) containing γ-secretase show contrasting sensitivity to MRK-560. Here, the authors determined cryo-EM structures of PS1/PS2-complexes treated with MRK-560 and identified key residues responsible for the isoform-dependent ...
Xuefei Guo +10 more
doaj +1 more source
High‐accuracy protein structure prediction in CASP14
Proteins: Structure, Function, and Bioinformatics, 2021 The application of state‐of‐the‐art deep‐learning approaches to the protein modeling problem has expanded the “high‐accuracy” category in CASP14 to encompass all targets.
J. Pereira +5 more
semanticscholar +1 more source