Results 11 to 20 of about 3,699,805 (346)
Uncovering protein structure [PDF]
Essays in Biochemistry, 2020 Abstract Structural biology is the study of the molecular arrangement and dynamics of biological macromolecules, particularly proteins. The resulting structures are then used to help explain how proteins function. This article gives the reader an insight into protein structure and the underlying chemistry and physics that is used to ...
Stollar, Elliott J., Smith, David P.
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CCharPPI web server: computational characterization of protein–protein interactions from structure [PDF]
, 2014 The atomic structures of protein–protein interactions are central to understanding their role in biological systems, and a wide variety of biophysical functions and potentials have been developed for their characterization and the construction of ...
Fernández-Recio, Juan +2 more
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PON-SC – program for identifying steric clashes caused by amino acid substitutions
BMC Bioinformatics, 2017 Background Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites.
Jelena Čalyševa, Mauno Vihinen
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Molecular basis for protein histidine N1-specific methylation of the “His-x-His” motifs by METTL9
Cell Insight, 2023 Histidine methylation serves as an intriguing strategy to introduce altered traits of target proteins, including metal ion chelation, histidine-based catalysis, molecular assembly, and translation regulation.
Wentao Zhao +6 more
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Representativeness of variation benchmark datasets
BMC Bioinformatics, 2018 Background Benchmark datasets are essential for both method development and performance assessment. These datasets have numerous requirements, representativeness being one.
Gerard C. P. Schaafsma, Mauno Vihinen
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Biomolecules, 2021 Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi +5 more
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Thermodynamic Prediction of Protein Neutrality [PDF]
, 2004 We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wildtype structure after one or more random amino acid substitutions.
Anfinsen +32 more
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Protein structure prediction [PDF]
International Journal of Modern Physics B, 2018 Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction.
Haiyou, Deng, Ya, Jia, Yang, Zhang
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Cell-based assays to identify novel retinoprotective agents
MethodsX, 2020 Degeneration of the retina can lead ultimately to devastating irreversible vision loss, such as in inherited retinitis pigmentosa and age-related macular degeneration. Currently there is no cure to prevent retinal degeneration.
Jeanee Bullock +2 more
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Functional properties of individual sub-domains of the fibrin(ogen) αC-domains
BBA Advances, 2023 Background: Fibrinogen is a large polyfunctional plasma protein consisting of a number of structural and functional domains. Among them, two αC-domains, each formed by the amino acid residues Аα392–610, are involved in fibrin polymerization, activation ...
Y.M. Stohnii +10 more
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