Results 31 to 40 of about 19,302,461 (314)

Identification of the Protein Glycation Sites in Human Myoglobin as Rapidly Induced by d-Ribose

Molecules, 2021
Protein glycation is an important protein post-translational modification and is one of the main pathogenesis of diabetic angiopathy. Other than glycated hemoglobin, the protein glycation of other globins such as myoglobin (Mb) is less studied.
Jing-Jing Liu, Yong You, Shu-Qin Gao, Shuai Tang, Lei Chen, Ge-Bo Wen, Ying-Wu Lin   +6 more
doaj   +1 more source

The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition

FEBS Open Bio, 2022
Highly pathogenic human coronaviruses (CoV) including SARS‐CoV, MERS‐CoV and SARS‐CoV‐2 have emerged over the past two decades, resulting in infectious disease outbreaks that have greatly affected public health.
Shuyuan Qiao, Shuyuan Zhang, Jiwan Ge, Xinquan Wang   +3 more
doaj   +1 more source

Improved protein structure prediction using predicted interresidue orientations

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Protein structure prediction is a longstanding challenge in computational biology. Through extension of deep learning-based prediction to interresidue orientations in addition to distances, and the development of a constrained optimization ...
Jianyi Yang, I. Anishchenko, Hahnbeom Park, Zhenling Peng, S. Ovchinnikov, D. Baker   +5 more
semanticscholar   +1 more source

Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein

Redox Biology, 2017
Infection with oncogenic human papillomavirus induces deregulation of cellular redox homeostasis. Virus replication and papillomavirus-induced cell transformation require persistent expression of viral oncoproteins E7 and E6 that must retain their ...
Gabriela Camporeale, Juan R. Lorenzo, Maria G. Thomas, Edgardo Salvatierra, Silvia S. Borkosky, Marikena G. Risso, Ignacio E. Sánchez, Gonzalo de Prat Gay, Leonardo G. Alonso   +8 more
doaj   +1 more source

Structure of the human marker of self 5-transmembrane receptor CD47

Nature Communications, 2021
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan   +15 more
doaj   +1 more source

Improved protein structure refinement guided by deep learning based accuracy estimation

Nature Communications, 2020
We develop a deep learning framework (DeepAccNet) that estimates per-residue accuracy and residue-residue distance signed error in protein models and uses these predictions to guide Rosetta protein structure refinement.
Naozumi Hiranuma, Hahnbeom Park, M. Baek, I. Anishchenko, J. Dauparas, D. Baker   +5 more
semanticscholar   +1 more source

Subtype-Specific HIV-1 Protease and the Role of Hinge and Flap Dynamics in Drug Resistance: A Subtype C Narrative

Viruses
The HIV-1 aspartic protease is an effective target for the treatment of HIV/AIDS. Current therapy utilizes a selection of nine protease inhibitors (PIs) in combination with other classes of antiretroviral drugs.
Dean Sherry, Zaahida Sheik Ismail, Tshele Mokhantso, Yasien Sayed   +3 more
doaj   +1 more source

RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Nature Communications, 2019
Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination which are removed by nucleases such as RuvC. Here the authors provide structural and biochemical details on the steps required for the completion of
Karolina Maria Górecka, Miroslav Krepl, Aleksandra Szlachcic, Jarosław Poznański, Jiří Šponer, Marcin Nowotny   +5 more
doaj   +1 more source

Biotransformation of Lignin by an Artificial Heme Enzyme Designed in Myoglobin With a Covalently Linked Heme Group

Frontiers in Bioengineering and Biotechnology, 2021
The conversion of Kraft lignin in plant biomass into renewable chemicals, aiming at harvesting aromatic compounds, is a challenge process in biorefinery.
Wen-Jie Guo, Jia-Kun Xu, Jing-Jing Liu, Jia-Jia Lang, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin, Ying-Wu Lin   +7 more
doaj   +1 more source

I-TASSER server: new development for protein structure and function predictions

Nucleic Acids Res., 2015
The I-TASSER server (http://zhanglab.ccmb.med.umich.edu/I-TASSER) is an online resource for automated protein structure prediction and structure-based function annotation. In I-TASSER, structural templates are first recognized from the PDB using multiple
Jianyi Yang, Yang Zhang
semanticscholar   +1 more source