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Critical assessment of methods of protein structure prediction (CASP)-Round XV. [PDF]
Proteins, 2023 Computing protein structure from amino acid sequence information has been a long‐standing grand challenge. Critical assessment of structure prediction (CASP) conducts community experiments aimed at advancing solutions to this and related problems ...
Kryshtafovych A +4 more
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Protein Structure Prediction in Drug Discovery [PDF]
Biomolecules, 2023 When the results of DeepMind’s AlphaFold2 at CASP were announced in 2020, the scientific world was so amazed by how effectively it performed that “it will change everything” became the motto for this revolution [...]
Alessandro Paiardini
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Highly accurate protein structure prediction with AlphaFold
Nature, 2021 Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1–4, the structures of around 100,000 unique proteins have been determined5, but this ...
Demis Hassabis +2 more
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Before and after AlphaFold2: An overview of protein structure prediction. [PDF]
Front Bioinform, 2023 Three-dimensional protein structure is directly correlated with its function and its determination is critical to understanding biological processes and addressing human health and life science problems in general.
Bertoline LMF +3 more
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Protein structure prediction has reached the single-structure frontier. [PDF]
Nat Methods, 2023 Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a
Lane TJ.
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Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning. [PDF]
Nat Biotechnol, 2023 While AlphaFold2 can predict accurate protein structures from the primary sequence, challenges remain for proteins that undergo conformational changes or for which few homologous sequences are known. Here we introduce AlphaLink, a modified version of the
Stahl K +4 more
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Prediction of protein structure [PDF]
Current Biology, 2000 Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.Nucleic Acids Res 1997, 25:3389-3402Bowie JU, Eisenberg D: Inverted protein structure prediction.
David Shortle
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Conformational ensembles for protein structure prediction [PDF]
Scientific ReportsAcquisition of conformational ensembles for a protein is a challenging task, which is actually involving to the solution for protein folding problem and the study of intrinsically disordered protein.
Jiaan Yang +9 more
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Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields, including biochemistry, medicine, physics, mathematics, and computer science.
Bin Huang +10 more
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The PSIPRED protein structure prediction server
Bioinform., 2000 SUMMARY The PSIPRED protein structure prediction server allows users to submit a protein sequence, perform a prediction of their choice and receive the results of the prediction both textually via e-mail and graphically via the web.
Liam J. McGuffin +2 more
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