Results 31 to 40 of about 1,677,396 (366)
FALCON2: a web server for high-quality prediction of protein tertiary structures
BMC Bioinformatics, 2021 Background Accurate prediction of protein tertiary structures is highly desired as the knowledge of protein structures provides invaluable insights into protein functions.
Lupeng Kong +4 more
doaj +1 more source
Progress in protein structure prediction? [PDF]
Trends in Biochemical Sciences, 1993 Prediction of protein secondary structure is an old problem and progress has been slow. Recently, spectacular success has been claimed in the blind prediction of the catalytic subunit of the cAMP-dependent protein kinase. When predictions in this and other test cases are assessed critically, some claims of prediction success turn out to be exaggerated,
ROST, B. +2 more
openaire +4 more sources
Non-H3 CDR template selection in antibody modeling through machine learning [PDF]
PeerJ, 2019 Antibodies are proteins generated by the adaptive immune system to recognize and counteract a plethora of pathogens through specific binding. This adaptive binding is mediated by structural diversity in the six complementary determining region (CDR ...
Xiyao Long +2 more
doaj +2 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Prediction of the protein secondary structure is a key issue in protein science. Protein secondary structure prediction (PSSP) aims to construct a function that can map the amino acid sequence into the secondary structure so that the protein secondary ...
Xin Jin +9 more
doaj +1 more source
CirPred, the first structure modeling and linker design system for circularly permuted proteins
BMC Bioinformatics, 2021 Background This work aims to help develop new protein engineering techniques based on a structural rearrangement phenomenon called circular permutation (CP), equivalent to connecting the native termini of a protein followed by creating new termini at ...
Teng-Ruei Chen +4 more
doaj +1 more source
Critical assessment of methods of protein structure prediction (CASP)—Round XIV
Proteins: Structure, Function, and Bioinformatics, 2021 Critical assessment of structure prediction (CASP) is a community experiment to advance methods of computing three‐dimensional protein structure from amino acid sequence. Core components are rigorous blind testing of methods and evaluation of the results
A. Kryshtafovych +4 more
semanticscholar +1 more source
TANKBind: Trigonometry-Aware Neural NetworKs for Drug-Protein Binding Structure Prediction
bioRxiv, 2022 Illuminating interactions between proteins and small drug molecules is a longstanding challenge in the field of drug discovery. Despite the importance of understanding these interactions, most previous works are limited by hand-designed scoring functions
Wei Lu +5 more
semanticscholar +1 more source
CASP11--An Evaluation of a Modular BCL::Fold-Based Protein Structure Prediction Pipeline. [PDF]
PLoS ONE, 2016 In silico prediction of a protein's tertiary structure remains an unsolved problem. The community-wide Critical Assessment of Protein Structure Prediction (CASP) experiment provides a double-blind study to evaluate improvements in protein structure ...
Axel W Fischer +7 more
doaj +1 more source
Jeeva: Enterprise Grid-enabled Web Portal for Protein Secondary Structure Prediction [PDF]
, 2008 This paper presents a Grid portal for protein secondary structure prediction developed by using services of Aneka, a .NET-based enterprise Grid technology.
Buyya, Rajkumar +3 more
core +3 more sources
(PS)2-v2: template-based protein structure prediction server
BMC Bioinformatics, 2009 Background Template selection and target-template alignment are critical steps for template-based modeling (TBM) methods. To identify the template for the twilight zone of 15~25% sequence similarity between targets and templates is still difficulty for ...
Hwang Jenn-Kang +2 more
doaj +1 more source