Protein Design is a Key Factor for Subunit-subunit Association [PDF]
arXiv, 1999 Fundamental questions about the role of the quaternary structures are addressed using a statistical mechanics off-lattice model of a dimer protein. The model, in spite of its simplicity, captures key features of the monomer-monomer interactions revealed ...
Carloni, Paolo +2 more
core +3 more sources
Understanding Protein-Complex Assembly through Grand Canonical Maximum Entropy Modeling [PDF]
Phys. Rev. Research 3, 033220 (2021), 2021 Inside a cell, heterotypic proteins assemble in inhomogeneous, crowded systems where the abundance of these proteins vary with cell types. While some protein complexes form putative structures that can be visualized with imaging, there are far more protein complexes that are yet to be solved because of their dynamic associations with one another.
arxiv +1 more source
Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. [PDF]
, 2012 Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before ...
Aliesky, Holly A +4 more
core +6 more sources
Quantum tunneling of three-spine solitons through excentric barriers [PDF]
Physics Letters A 2022; 448: 128319, 2022 Macromolecular protein complexes catalyze essential physiological processes that sustain life. Various interactions between protein subunits could increase the effective mass of certain peptide groups, thereby compartmentalizing protein $\alpha$-helices.
arxiv +1 more source
The cDNA and deduced amino acid sequence of the γ subunit of the L-type calcium channel from rabbit skeletal muscle [PDF]
, 1990 Complementary DNAs for the γ subunit of the calcium channel of rabbit skeletal muscle were isolated on the basis of peptide sequences derived from the purified protein.
Biel +30 more
core +1 more source
The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information [PDF]
, 1987 The NH2 terminus of the yeast F1-ATPase beta subunit precursor directs the import of this protein into mitochondria. To define the functionally important components of this import signal, oligonucleotide-directed mutagenesis was used to introduce a ...
Bedwell, David M. +2 more
core +1 more source
Mitochondrial Protein Import [PDF]
, 1987 The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Arends +72 more
core +4 more sources
Determinants of the voltage dependence of G protein modulation within calcium channel β subunits [PDF]
, 2008 CaVβ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although Gβγ-mediated inhibitory
A Hummer +45 more
core +2 more sources
Modulation of cardiac Ca2+ channels in Xenopus oocytes by protein kinase C [PDF]
, 1992 L-Type calcium channel was expressed in Xenopus laevis oocytes injected with RNAs coding for different cardiac Cu2+ channel subunits, or with total heart RNA.
Biel +54 more
core +1 more source
Mass Fractal Dimension of the Ribosome and Implication of its Dynamic Characteristics [PDF]
Physical Review E 73, 042901 (2006), 2006 Self-similar properties of the ribosome in terms of the mass fractal dimension are investigated. We find that both the 30S subunit and the 16S rRNA have fractal dimensions of 2.58 and 2.82, respectively; while the 50S subunit as well as the 23S rRNA has the mass fractal dimension close to 3, implying a compact three dimensional macromolecule.
arxiv +1 more source