Results 11 to 20 of about 1,159,139 (296)

ECMpy, a Simplified Workflow for Constructing Enzymatic Constrained Metabolic Network Model

Biomolecules, 2022
Genome-scale metabolic models (GEMs) have been widely used for the phenotypic prediction of microorganisms. However, the lack of other constraints in the stoichiometric model often leads to a large metabolic solution space being inaccessible. Inspired by
Zhitao Mao, Xin Zhao, Xue Yang, Peiji Zhang, Jiawei Du, Qianqian Yuan, Hongwu Ma   +6 more
doaj   +1 more source

An Overview of SARS-CoV-2 Etiopathogenesis and Recent Developments in COVID-19 Vaccines

Biomolecules, 2023
The Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has significantly impacted the health and socioeconomic status of humans worldwide.
Dona Susan Mathew, Tirtha Pandya, Het Pandya, Yuzen Vaghela, Selvakumar Subbian   +4 more
doaj   +1 more source

Tetravalent SARS-CoV-2 S1 subunit protein vaccination elicits robust humoral and cellular immune responses in SIV-infected rhesus macaque controllers

mBio, 2023
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for safe and effective vaccines to be rapidly developed and distributed worldwide, especially considering the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
Muhammad S. Khan, Eun Kim, Quentin Le Hingrat, Adam Kleinman, Alessandro Ferrari, Jose C. Sammartino, Elena Percivalle, Cuiling Xu, Shaohua Huang, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Ivona Pandrea, Andrea Gambotto, Cristian Apetrei   +14 more
doaj   +1 more source

Immunogenicity and safety of Biological E’s CORBEVAX™ vaccine compared to COVISHIELD™ (ChAdOx1 nCoV-19) vaccine studied in a phase-3, single blind, multicentre, randomized clinical trial

Human Vaccines & Immunotherapeutics, 2023
Optimum formulation of Biological-E’s protein subunit CORBEVAX™ vaccine was selected in phase-1 and -2 studies and found to be safe and immunogenic in healthy adult population.
Subhash Thuluva, Vikram Paradkar, SubbaReddy Gunneri, Vijay Yerroju, Rammohan Mogulla, Pothakamuri Venkata Suneetha, Kishore Turaga, Mahesh Kyasani, Senthil Kumar Manoharan, Srikanth Adabala, Aditya Sri Javvadi, Guruprasad Medigeshi, Janmejay Singh, Heena Shaman, Akshay Binayke, Aymaan Zaheer, Amit Awasthi, Chandramani Singh, Venkateshwar Rao A, Indranil Basu, Khobragade Akash Ashok Kumar, Anil Kumar Pandey   +21 more
doaj   +1 more source

Carbohydrate Ligands for COVID-19 Spike Proteins

Viruses, 2022
An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022 ...
Yung-Kuo Lee, Wen-Chiu Chang, Ekambaranellore Prakash, Yu-Ju Peng, Zhi-Jay Tu, Chun-Hung Lin, Pang-Hung Hsu, Chuan-Fa Chang   +7 more
doaj   +1 more source

Subunit interactions of the Go protein [PDF]

FEBS Letters, 1992
The monoclonal antibody, MONO, recognizes an epitope on the G protein αo‐subunit [van der Voorn et al., submitted] and readily immunoprecipitates heterotrimeric Go proteins from solubilized, crude bovine brain membranes, as well as from a purified bovine brain G protein preparation.
Trudi Hengeveld, Loesje van der Voorn, Hidde L. Ploegh   +2 more
openaire   +2 more sources

The effect of signal pathways on the neural KATP subunits SUR1/Kir6.2 expression induced by Aβ1-42

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To investigate the potential signal transduction mechanism of β⁃amyloid protein1-42 (Aβ1-42) induced up⁃regulation of ATP sensitive potassium channel KATP subunit SUR1/Kir6.2 proteins expression.
LI Yan⁃ju, ZHANG Ge , WANG Xiao⁃jing, XING Xiao⁃min, MA Guo⁃zhao   +4 more
doaj   +1 more source

Self-subunit swapping occurs in another gene type of cobalt nitrile hydratase. [PDF]

PLoS ONE, 2012
Self-subunit swapping is one of the post-translational maturation of the cobalt-containing nitrile hydratase (Co-NHase) family of enzymes. All of these NHases possess a gene organization of , which allows the activator protein to easily form a ...
Yi Liu, Wenjing Cui, Yuanyuan Xia, Youtian Cui, Michihiko Kobayashi, Zhemin Zhou   +5 more
doaj   +1 more source

Influence of Conformation of M. tuberculosis RNase P Protein Subunit on Its Function. [PDF]

PLoS ONE, 2016
RNase P is an essential enzyme that processes 5' end leader sequence of pre-tRNA to generate mature tRNA. The bacterial RNase Ps contain a RNA subunit and one protein subunit, where the RNA subunit contains the catalytic activity.
Alla Singh, Shah Ubaid-ullah, Anup K Ramteke, Janendra K Batra   +3 more
doaj   +1 more source

Direct Interaction of Avian Cryptochrome 4 with a Cone Specific G-Protein

Cells, 2022
Background: Night-migratory birds sense the Earth’s magnetic field by an unknown molecular mechanism. Theoretical and experimental evidence support the hypothesis that the light-induced formation of a radical-pair in European robin cryptochrome 4a ...
Katharina Görtemaker, Chad Yee, Rabea Bartölke, Heide Behrmann, Jan-Oliver Voß, Jessica Schmidt, Jingjing Xu, Vita Solovyeva, Bo Leberecht, Elmar Behrmann, Henrik Mouritsen, Karl-Wilhelm Koch   +11 more
doaj   +1 more source