Results 21 to 30 of about 1,322,999 (349)

How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism. [PDF]

PLoS ONE, 2011
Many critical cellular functions are performed by multisubunit circular protein oligomers whose internal geometry has evolved to meet functional requirements.
Chao-Sheng Chen, Callum Smits, Guy G Dodson, Mikhail B Shevtsov, Natalie Merlino, Paul Gollnick, Alfred A Antson   +6 more
doaj   +1 more source

Structure of the Saccharolobus solfataricus type III-D CRISPR effector

Current Research in Structural Biology, 2023
CRISPR-Cas is a prokaryotic adaptive immune system, classified into six different types, each characterised by a signature protein. Type III systems, classified based on the presence of a Cas10 subunit, are rather diverse multi-subunit assemblies with a ...
Giuseppe Cannone, Dmytro Kompaniiets, Shirley Graham, Malcolm F. White, Laura Spagnolo   +4 more
doaj   +1 more source

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits [PDF]

, 2008
CaVβ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although Gβγ-mediated inhibitory
A Hummer, A Meir, A Neely, AC Dolphin, AC Meir A Dolphin, AJ Butcher, Andriy V. Dresviannikov, Annette C. Dolphin, B Li, C Altier, C Canti, C Canti, D Bichet, D Walker, DC Bell, EA Ertel, F Bertaso, F Petegem Van, G Sandoz, GJ Stephens, GJ Stephens, J Barclay, J Leroy, Jerôme Leroy, JM Maltez, Karen M. Page, KM Page, L Berrou, L Birnbaumer, LP Jones, M Pragnell, M Waard De, MR Hanlon, MW Richards, MW Richards, N Qin, N Weiss, NL Brice, RM Cohen, SC Stotz, SX Takahashi, SX Takahashi, WA Catterall, Wendy S. Pratt, Y Opatowsky, YH Chen   +45 more
core   +2 more sources

Subunit Exchange in Protein Complexes

Journal of Molecular Biology, 2018
Over the past 50 years, protein complexes have been studied with techniques such as X-ray crystallography and electron microscopy, generating images which although detailed are static and homogeneous. More recently, limited application of in vivo fluorescence and other techniques has revealed that many complexes previously thought stable and ...
Tusk, S, Delalez, N, Berry, R
openaire   +2 more sources

The G Protein γ Subunit [PDF]

Journal of Biological Chemistry, 1995
Guanine nucleotide-binding protein beta and gamma subunits form a tightly bound complex that can only be separated by denaturation. Assembly of beta and gamma subunits is a complicated process. The beta 1 and gamma 2 subunits can be synthesized in vitro in rabbit reticulocyte lysate and then assembled into dimers, but beta 1 cannot form beta gamma ...
Denise J. Spring, Carl J. Schmidt, Eva J. Neer, Fei Yi, Ulrike Mende   +4 more
openaire   +3 more sources

The Est3 protein is a subunit of yeast telomerase [PDF]

Current Biology, 2000
EST1, EST2, EST3 and TLC1 function in a single pathway for telomere replication in the yeast Saccharomyces cerevisiae [1] [2], as would be expected if these genes all encode components of the same complex. Est2p, the reverse transcriptase protein subunit, and TLC1, the templating RNA, are subunits of the catalytic core of yeast telomerase [3] [4] [5 ...
Sara K. Evans, Rodney G. Weilbaecher, Victoria Lundblad, Timothy P. Hughes   +3 more
openaire   +3 more sources

Interaction between the assembly of the ribosomal subunits: Disruption of 40S ribosomal assembly causes accumulation of extra-ribosomal 60S ribosomal protein uL18/L5. [PDF]

PLoS ONE, 2020
Inhibition of the synthesis of an essential ribosomal protein (r-protein) abrogates the assembly of its cognate subunit, while assembly of the other subunit continues.
Nusrat Rahman, Md Shamsuzzaman, Lasse Lindahl   +2 more
doaj   +1 more source

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Arends, Argan, Argan, Bogner, Bogner, Bradford, Böhni, Böhni, Chamberlain, Chen, Chen, Conboy, Eilers, Emr, Firgaira, Flügge, Frank, Gasser, Geller, Grossman, Gubler, Hanahan, Hansen, Harmey, Hartl, Hay, Hennig, Hennig, Horwich, Hurt, Hurt, Jaenicke, Keng, Kolanski, Maniatis, McAda, Miura, Miura, Mueckler, Nicholls, Nunberg, Ohta, Pelham, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Randall, Riezman, Roise, Rothblatt, Rothman, Schlenstedt, Schleyer, Schleyer, Schleyer, Schmidt, Schmidt, Schwaiger, Sebald, Stueber, van Loon, van Loon, Viebrock, Waters, Wiech, Wikstrom, Zimmermann, Zimmermann, Zwizinski, Zwizinski, Zwizinski   +72 more
core   +1 more source

The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex [PDF]

, 2013
The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia.
A Sisto, AE Lang, C Gatsogiannis, C McNulty, CP Silva, D Bowen, D Liu, D Zhang, DL Erickson, EF Boyd, Frederick M. Ausubel, G Yang, Guowei Yang, H Gotoh, H Li, I Gendlina, J Soding, JJ Sheets, M Blackburn, M Blackburn, M Sergeant, MC Hares, MJ Landsberg, MR Hurst, N Waterfield, N Waterfield, Nicholas R. Waterfield, NR Waterfield, NR Waterfield, NR Waterfield, R Ffrench-Constant, R Zhao, SC Lee, SK Aoki, SM Tennant, VL Kung, YD Wang, ZC Ruhe   +37 more
core   +3 more sources

Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen. [PDF]

, 2016
Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far, proven the most efficacious. Recently, subunit A of the V-type ATP synthase (ATPase; TC0582) complex
Barta, Michael L, de la Maza, Luis M, Hefty, P Scott, Pal, Sukumar, Tifrea, Delia F   +4 more
core   +1 more source