Results 11 to 20 of about 11,322,924 (398)

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

eLife, 2016
Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays.
Emiko Mihara, Hidenori Hirai, Hideki Yamamoto, Keiko Tamura-Kawakami, Mami Matano, Akira Kikuchi, Toshiro Sato, Junichi Takagi   +7 more
doaj   +1 more source

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean   +20 more
doaj   +1 more source

Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2

Nature Communications, 2021
Hoshino et al., engineer a human virus receptor, hACE2, and demonstrate its potential for overcoming SARS-CoV-2 mutations that otherwise hinder therapeutic interventions.
Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Emiko Mihara, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura, Yusuke Sakai, Yumi Itoh, Fuminori Sugihara, Yoshiharu Matsuura, Satoaki Matoba, Toru Okamoto, Junichi Takagi, Atsushi Hoshino   +17 more
doaj   +1 more source

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

Science, 2019
Local translation in presynaptic terminals Proteins carry out most of the functions in cells, including neurons, which are one of the most morphologically complex cell types in the body.
Anne-Sophie Hafner, Paul G. Donlin-Asp, Beulah Leitch, Etienne Herzog, E. Schuman   +4 more
semanticscholar   +1 more source

Biochemical aspects of bacterial strategies for handling the incomplete translation processes

Frontiers in Microbiology, 2014
During protein synthesis in cells, translating ribosomes may encounter abnormal situations that lead to retention of immature peptidyl-tRNA on the ribosome due to failure of suitable termination processes.
Yoshihiro eShimizu
doaj   +1 more source

Phase-dependent molecular requirements for memory reconsolidation: differential roles for protein synthesis and protein kinase A activity [PDF]

, 2006
After consolidation, a process that requires gene expression and protein synthesis, memories are stable and highly resistant to disruption by amnestic influences.
Kemenes, György, Kemenes, Ildikó, Michel, Maximilian, Mueller, Uli, Papp, Andrea   +4 more
core   +1 more source

2D hybrid analysis: Approach for building three-dimensional atomic model by electron microscopy image matching

Scientific Reports, 2017
In this study, we develop an approach termed “2D hybrid analysis” for building atomic models by image matching from electron microscopy (EM) images of biological molecules.
Atsushi Matsumoto, Naoyuki Miyazaki, Junichi Takagi, Kenji Iwasaki   +3 more
doaj   +1 more source

RETRACTED ARTICLE: Novel magnetic organic–inorganic hybrids based on aromatic polyamides and ZnFe2O4 nanoparticles with biological activity

Scientific Reports, 2021
Magnetic nanoparticles were creatively selected as stable, inexpensive, biodegradable, facile recoverable, and functionalizable supports for a variety of synthetic and natural polymers.
Reza Eivazzadeh-Keihan, Mostafa Ghafori Gorab, Hooman Aghamirza Moghim Aliabadi, Mohammad mahdavi, Ali Reza Akbarzadeh, Ali Maleki, Hossein Ghafuri   +6 more
doaj   +1 more source

Local protein synthesis in axon terminals and dendritic spines differentiates plasticity contexts

bioRxiv, 2018
While there is ample evidence for localized mRNAs and protein synthesis in mature neuronal postsynaptic compartments, clear demonstrations of these processes in presynaptic terminals are extremely limited.
Anne-Sophie Hafner, Paul G. Donlin-Asp, B. Leitch, E. Herzog, E. Schuman   +4 more
semanticscholar   +1 more source

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

eLife, 2017
eIF4A is a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5'-untranslated regions (UTRs) of mRNAs to promote their recruitment to the eukaryotic translation pre-initiation complex (PIC).
Paul Yourik, Colin Echeverría Aitken, Fujun Zhou, Neha Gupta, Alan G Hinnebusch, Jon R Lorsch   +5 more
doaj   +1 more source