Results 11 to 20 of about 13,924,024 (337)

Deubiquitinase-targeting chimeras for targeted protein stabilization [PDF]

Nature Chemical Biology, 2022
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to ...
Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew J. Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura   +23 more
openaire   +4 more sources

Chemodivergent assembly of ortho-functionalized phenols with tunable selectivity via rhodium(III)-catalyzed and solvent-controlled C-H activation

Communications Chemistry, 2021
Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the ...
Haiman Zhang, Shuang Lin, Hui Gao, Kaixin Zhang, Yi Wang, Zhi Zhou, Wei Yi   +6 more
doaj   +1 more source

Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030.
Karina Ramírez-Alarcón, Montserrat Victoriano, Lorena Mardones, Marcelo Villagran, Marcelo Villagran, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Natália Cruz-Martins, Natália Cruz-Martins, Natália Cruz-Martins, Javad Sharifi-Rad, Javad Sharifi-Rad, Miquel Martorell, Miquel Martorell, Miquel Martorell   +14 more
doaj   +1 more source

MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants

Frontiers in Immunology, 2021
Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been developed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Antibody therapeutics are effective in neutralizing the virus and reducing
Sua Lee, Shina Jang, Jihoon Kang, Soo Bin Park, Young Woo Han, Hyemi Nam, Munkyung Kim, Jeewon Lee, Ki Joon Cho, Jeonghun Kim, Miyoung Oh, Jihye Ryu, Jong Hyeon Seok, Yunhwa Kim, Jee-Boong Lee, Man-Seong Park, Yong-Sung Kim, Hosun Park, Dong-Sik Kim, Dong-Sik Kim   +19 more
doaj   +1 more source

Amphiphilic Aminated Derivatives of [60]Fullerene as Potent Inhibitors of Tumor Growth and Metastasis

Advanced Science, 2022
Malignant proliferation and metastasis are the hallmarks of cancer cells. Aminated [70]fullerene exhibits notable antineoplastic effects, promoting it a candidate for multi‐targeted cancer drugs.
Jiawei Huo, Jie Li, Yang Liu, Libin Yang, Xinran Cao, Chong Zhao, Yicheng Lu, Wei Zhou, Shumu Li, Jianan Liu, Jiao Li, Xing Li, Jing Wan, Rui Wen, Mingming Zhen, Chunru Wang, Chunli Bai   +16 more
doaj   +1 more source

Design of protein-binding proteins from the target structure alone

Nature, 2022
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5.
Longxing Cao, B. Coventry, Inna Goreshnik, Buwei Huang, W. Sheffler, J. Park, K. Jude, I. Marković, R. Kadam, K. Verschueren, K. Verstraete, S. Walsh, N. Bennett, A. Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora K. Picton, L. Miller, Eva-Maria Strauch, Nic Debouver, Allison Pires, A. Bera, Samer F. Halabiya, Bradley Hammerson, Wei Yang, S. Bernard, L. Stewart, I. Wilson, H. Ruohola-Baker, J. Schlessinger, Sangwon Lee, S. Savvides, K. Garcia, D. Baker   +34 more
semanticscholar   +1 more source

Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Frontiers in Immunology, 2022
More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor. We
Bo-Seong Jeong, Joon Young Jeon, Chih-Jen Lai, Hye-Yeoung Yun, Jae U. Jung, Byung-Ha Oh, Byung-Ha Oh   +6 more
doaj   +1 more source

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away

Cell Reports, 2023
Summary: Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antibody receptor and E3 ubiquitin ligase that promotes destruction of a broad range of pathogens.
Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter   +2 more
doaj   +1 more source

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers [PDF]

, 2010
Protein self-organization is essential for the establishment and maintenance of nuclear architecture and for the regulation of gene expression. We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric
A. Sawasdichai, A. Shukla, A. Soufi, Bess, Butcher, C. Smith, Cai, Cairns, Crompton, D'Elia, Dafforn, de Los Rios, Desjobert, Galande, Gaston, Gaston, Gaston, Goldman, Jennings, K. Gaston, Katsani, Larquet, Lennard, Luger, Luijsterburg, Martino, Mohd-Sarip, P. Noy, P.-S. Jayaraman, Puppin, Sekiya, Song, Soufi, Soufi, Soufi, T. Dafforn, Tanny, Thaw, Topisirovic, Vernon, Williams, Yasui   +41 more
core   +6 more sources

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

Cell Reports, 2021
Summary: Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and ...
Paul R. Elliott, Derek Leske, Jane Wagstaff, Lisa Schlicher, Georgina Berridge, Sarah Maslen, Frederik Timmermann, Biao Ma, Roman Fischer, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen   +11 more
doaj   +1 more source