Results 21 to 30 of about 13,924,024 (337)

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
core   +2 more sources

PROTACs targeting epigenetic proteins

Acta Materia Medica, 2023
The field of epigenetics pertains to alterations in gene function that are inherited without changes in the DNA sequence, including histone modifications, post-translational modifications of amino acids, and covalent modifications of DNA bases. These alteration pathways modulate the transformation of genotypes into specific phenotypes.
Chao Zhang, Yuna He, Xiuyun Sun, Wenyi Wei, Yanlong Liu, Yu Rao   +5 more
openaire   +3 more sources

Utilization of macrocyclic peptides to target protein-protein interactions in cancer

Frontiers in Oncology, 2022
Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated PPIs are involved in the process of various diseases, including cancer.
Jiawen Yang, Jiawen Yang, Jiawen Yang, Qiaoliang Zhu, Yifan Wu, Yifan Wu, Yifan Wu, Xiaojuan Qu, Xiaojuan Qu, Xiaojuan Qu, Haixia Liu, Haixia Liu, Haixia Liu, Biao Jiang, Biao Jiang, Di Ge, Xiaoling Song   +16 more
doaj   +1 more source

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H., Gething, M. J., Klenk, H. D., Koszinowski, Ulrich H., Waterfield, M. D.   +4 more
core   +2 more sources

Supramolecular Chemistry Targeting Proteins

Journal of the American Chemical Society, 2017
The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials.
Sam van Dun, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld   +3 more
openaire   +2 more sources

Modeling protein target search in human chromosomes

Physical Review Research, 2021
Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion ...
Markus Nyberg, Tobias Ambjörnsson, Per Stenberg, Ludvig Lizana   +3 more
doaj   +1 more source

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]

, 2014
Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A., Best, Andrew, Chabot, Benoit, Cheong Lee, Ka, Cowell, Ian G., Curk, Tomaz, Dalgliesh, Caroline, Danilenko, Marina, Elliott, David J., Hong, Elaine, Hussain, Rafiq, James, Katherine, Keavney, Bernard, Kheirolahi-Kouhestani, Mahsa, Klinck, Roscoe, Santibanez Koref, Mauro, Tyson-Capper, Alison, Venables, Julian P., Wipat, Anil, Xu, Yaobo   +19 more
core   +2 more sources

Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker.

Bioanalysis, 2017
AIM IP-10 is a protein target for the treatment of Crohn's disease. Inhibition of IP-10 by anti-IP-10 mAbs neutralizes its various biological activities.
Hongwei Zhang, Huidong Gu, P. Shipkova, Eugene Ciccimaro, Huadong Sun, Qihong Zhao, T. Olah   +6 more
semanticscholar   +1 more source

PRODUCTION OF SARS-COV-2 MEMBRANE PROTEIN AS BETTER TARGET PROTEIN FOR DIAGNOSTIC APPLICATION

International Journal of Infectious Diseases, 2023
Intro: The COVID-19 pandemic is caused by the SARS-CoV-2 virus, an enveloped RNA of the coronavirus family. The advancement in molecular technology and biochemistry has accelerated the development of diagnostic reagents and assays.
N.A. Mat Rahim, J. Zahidi, N.A. Amir Hashim, N.A. Nor Amdan, H.F. Zamri, M.R. Mohd Ali, R. Mohd Zain, N. Ahmad   +7 more
doaj   +1 more source

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]

, 2015
Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A., Goto, G.H., Henry, E., Ogi, H., Sugimoto, K., Zencir, Sevil   +5 more
core   +1 more source