Results 31 to 40 of about 13,924,024 (337)
Molecular Biomedicine, 2023 Immunocompromised individuals are particularly vulnerable to viral infections and reactivation, especially endogenous herpes viruses such as Epstein-Barr virus (EBV), a member of oncogenic gamma-herpesviruses, which are commonly linked to pneumonia and ...
Aiping Qin +11 more
doaj +1 more source
Hyperglycemia triggers HIPK2 protein degradation [PDF]
, 2016 Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing
Baldari, Silvia +6 more
core +2 more sources
International Journal of Molecular Sciences, 2016 Molecular docking is a computational chemistry method which has become essential for the rational drug design process. In this context, it has had great impact as a successful tool for the study of ligand–receptor interaction modes, and for the ...
D. Ramírez, Julio Caballero
semanticscholar +1 more source
The Nucleocapsid Protein of SARS–CoV-2: a Target for Vaccine Development
Journal of Virology, 2020 During the current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2), there has been an unprecedented level of global collaboration that has led to a rapid characterization of SARS–CoV-2 ...
N. K. Dutta, K. Mazumdar, James T. Gordy
semanticscholar +1 more source
Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. [PDF]
, 2004 Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Li, Hao +2 more
core +4 more sources
Roles of cofactors and chromatin accessibility in Hox protein target specificity
Epigenetics & Chromatin, 2016 The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is still poorly understood.
C. Beh +5 more
semanticscholar +1 more source
Optimal TELSAM-Target Protein Linker Character is Target Protein-Dependent [PDF]
Structural DynamicsThe fusion of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest has been shown to significantly enhance crystallization propensity and improve diffraction quality.
Maria Jose P Romo +19 more
doaj +1 more source
Targeted Antithrombotic Protein Micelles [PDF]
Angewandte Chemie International Edition, 2014 AbstractActivated platelets provide a promising target for imaging inflammatory and thrombotic events along with site‐specific delivery of a variety of therapeutic agents. Multifunctional protein micelles bearing targeting and therapeutic proteins were now obtained by one‐pot transpeptidation using an evolved sortase A.
Wookhyun, Kim +7 more
openaire +2 more sources
BMC Bioinformatics, 2022 Background Target drugs play an important role in the clinical treatment of virus diseases. Virus-encoded proteins are widely used as targets for target drugs.
Shengrong Xia +7 more
doaj +1 more source
Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]
, 2013 Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter +2 more
core +2 more sources