Results 41 to 50 of about 13,924,024 (337)
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]
, 2015 G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie +4 more
core +3 more sources
Signal Transduction and Targeted Therapy, 2020 Natural products are an important source of new drugs for the treatment of various diseases. However, developing natural product-based new medicines through random moiety modification is a lengthy and costly process, due in part to the difficulties ...
Xiao Chen +9 more
semanticscholar +1 more source
Identification of oleoylethanolamide as an endogenous ligand for HIF-3α
Nature Communications, 2022 Whether hypoxia-inducible factors (HIFs) can be directly regulated by endogenous small molecules is a long-standing question. Here authors identified the metabolite oleoylethanolamide as a HIF-3α ligand and further revealed its mechanism of action.
Xiaotong Diao +15 more
doaj +1 more source
Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is frequently lethal and has no effective pharmaceutical treatment, posing a great threat to human health. Previous bioinformatics studies of the mechanisms underlying AAA relied largely on the detection of direct protein ...
Kexin Zhang +4 more
doaj +1 more source
Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy
Frontiers in Cellular Neuroscience, 2021 Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized, and highly permeable blood vessels with intermittent blood flow.
Cinzia Cocola +32 more
doaj +1 more source
An extra dimension in protein tagging by quantifying universal proteotypic peptides using targeted proteomics [PDF]
, 2016 The use of protein tagging to facilitate detailed characterization of target proteins has not only revolutionized cell biology, but also enabled biochemical analysis through efficient recovery of the protein complexes wherein the tagged proteins reside ...
De Sutter, Delphine +9 more
core +2 more sources
Nature Communications, 2015 We report the crystal structure of a 40mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein ...
D. Oberthür +8 more
semanticscholar +1 more source
Protein Interactome of Amyloid-β as a Therapeutic Target
Pharmaceuticals, 2023 The amyloid concept of Alzheimer’s disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells, causing their malfunction and death.
Vladimir F. Lazarev +4 more
doaj +1 more source
Protein search for multiple targets on DNA [PDF]
, 2015 Protein-DNA interactions are crucial for all biological processes. One of the most important fundamental aspects of these interactions is the process of protein searching and recognizing specific binding sites on DNA.
Alberts B. +5 more
core +2 more sources
Leukemia, 2012 Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon (CRBN) has been identified as the primary teratogenic target of thalidomide.
A. Lopez-Girona +19 more
semanticscholar +2 more sources