Results 261 to 270 of about 1,447,276 (313)

Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting. [PDF]

Sci Rep
Lazzaretti C, Roy N, Paradiso E, Capponi C, Ferrari T, Reggianini F, Sperduti S, Perri C, Baschieri L, Mascolo E, Varani M, Canu G, Trenti T, Nicoli A, Morini D, Iannotti F, Villani MT, Vicini E, Simoni M, Casarini L.   +19 more
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Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage IV NSCLC. [PDF]

JTO Clin Res Rep
Rolfo C, Greillier L, Veillon R, Badin F, Ghiringhelli F, Isambert N, Paulus A, Chaudhary SP, Vugmeyster Y, Sato M, Hiret S.   +10 more
europepmc   +1 more source

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Protein targeting to peroxisomes

Biochemical Society Transactions, 1990
Peroxisomes are single-membrane-bound organelles that have important functions in cell metabolism. They are almost ubiquitous in eukaryotic cells and biochemical findings over the past 10 years have shown that they are involved in cell respiration, and also play a significant role in lipid metabolism (for reviews, see [ l , 21).
G M, Small, A S, Lewin
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Targeting of lysosomal proteins

Seminars in Cell & Developmental Biology, 2000
Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular, the acid hydrolase receptors are retrieved to the TGN.
Y, Rouillé, W, Rohn, B, Hoflack
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Targeting of proteins into chloroplasts

BioEssays, 1988
AbstractCytoplasmically synthesized proteins are directed into chloroplasts by amino terminal transit sequences of the precursor proteins. For proteins of the thylakoid lumen, transit sequences are also important in directing proteins to the lumen.
K, Keegstra, C, Bauerle
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Targeting of Motor Proteins

Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Protein Targeting in the Neuron

Annual Review of Neuroscience, 1993
The morphology of the neuron is essential to its function. Each mor­ phological specialization of the neuron, the dendrite, the dendritic spines, the axon, the axon hillock, the nodes of Ranvier, the active zone, and the synaptic vesicle appears to have a unique protein composition.
R B, Kelly, E, Grote
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Protein targeting and protein secretion

Genome, 1989
The two scheduled workshops entitled Protein Secretion and Protein Targeting were combined into a single session on Monday, August 22, before a large audience. We record here the highlights of these talks, which supplement the information already available in the published abstracts.
M E, Dumont, F, Sherman, D Y, Thomas
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Proteolysis-targeting Chimeras for Targeting Protein for Degradation

Future Medicinal Chemistry, 2019
Proteolysis-targeting chimeras (PROTACs) are an emerging tool for therapeutic intervention by reducing or eliminating disease-causing proteins. PROTACs are bifunctional molecules that consist of a target protein ligand, a linker and an E3 ligase ligand, which mediate the polyubiquitination of the target protein, ultimately leading to the target protein
Jianguo, Qi, Gang, Zhang
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