Results 51 to 60 of about 1,760,654 (353)
MoleculesSignal transduction and homeostasis are regulated by complex protein interactions in the intracellular environment. Therefore, the transportation of impermeable macromolecules (nucleic acids, proteins, and drugs) that control protein interactions is ...
Akari Miwa, Koki Kamiya
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]
, 2017 Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela +7 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
CoCl2‐induced glioma hypoxia environment enhances CD47‐SIRPα to promote tumor immune evasion
MedComm – OncologyElevated levels of tumor‐associated macrophages and microglia in the immune microenvironment of malignant gliomas promote tumor growth and progression.
Xiangfei Ding +8 more
doaj +1 more source
Non-Markovian Quantum Jumps in Excitonic Energy Transfer [PDF]
, 2009 We utilize the novel non-Markovian quantum jump (NMQJ) approach to stochastically simulate exciton dynamics derived from a time-convolutionless master equation.
Alán Aspuru-Guzik +4 more
core +2 more sources
Transport o proteins into mitochondria [PDF]
Current Opinion in Cell Biology, 1989 The transfer of cytoplasmically synthesized precursor proteins into or across the inner mitochondrial membrane is dependent on energization of the membrane. To investigate the role of this energy requirement, a buffer system was developed in which efficient import of ADP/ATP carrier into mitochondria from the receptor-bound state occurred.
Pfanner, Nikolaus, Neupert, Walter
openaire +5 more sources
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Frontiers in Microbiology, 2020 The proper functioning of many proteins requires their transport to the correct cellular compartment or their secretion. Signal recognition particle (SRP) is a major protein transport pathway responsible for the co-translational movement of integral ...
Runhua Han +10 more
doaj +1 more source
Modulation of the ISFET response by an immunological reaction [PDF]
, 1989 A new method is presented for the detection of an immunological reaction in a membrane. Antigens (or antibodies) are taken up in a porous membrane, which covers the gate area of an ISFET. By stepwise changing of the electrolyte concentration, a transient
Bergveld, P. +4 more
core +2 more sources