Results 51 to 60 of about 1,594,666 (333)

H+ transport is an integral function of the mitochondrial ADP/ATP carrier. [PDF]

, 2019
The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP.
Angelin, Alessia, Bertholet, Ambre M, Cho, Joonseok, Chouchani, Edward T, Fedorenko, Andriy, Garrity, Ryan, Kazak, Lawrence, Kirichok, Yuriy, Long, Jonathan Z, Spiegelman, Bruce M, Terada, Naohiro, Vidoni, Sara, Wallace, Douglas C   +12 more
core   +1 more source

Enhancing effect of natural adjuvant, panduratin A, on antibacterial activity of colistin against multidrug-resistant Acinetobacter baumannii

Scientific Reports
Colistin- and carbapenem-resistant Acinetobacter baumannii is a serious multidrug resistant (MDR) bacterium in clinical settings. Discovery of new antibacterial drugs against MDR is facing multiple challenges in drug development.
Nalumon Thadtapong, Soraya Chaturongakul, Chanita Napaswad, Padungsri Dubbs, Sunhapas Soodvilai   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Drive, filter, and stick: A protein sorting conspiracy in photoreceptors. [PDF]

, 2019
The sorting of proteins into different functional compartments is a fundamental cellular task. In this issue, Maza et al. (2019. J. Cell Biol https://doi.org/10.1083/jcb.201906024) demonstrate that distinct protein populations are dynamically generated ...
Aidan I. Brown, Besharse, Brangwynne, Elena F. Koslover, Goehring, Hagins, Hu, Lechtreck, Maza, Schlager, Stojanovski, Tas, Wente   +12 more
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Purification and Reconstitution of the Glutamate Carrier GltT of the Thermophilic Bacterium Bacillus stearothermophilus [PDF]

, 1995
An affinity tag consisting of six adjacent histidine residues followed by an enterokinase cleavage site was genetically engineered at the N-terminus of the glutamate transport protein GltT of the thermophilic bacterium Bacillus stearothermophilus.
Bassilana M., Deguchi Y., Heyne R. I. R., Hirata H., Hochuli E., Kaback H. R., Knol J., Lolkema J. S., Lolkema J. S., Newman M. J., Pines G., Poolman B., Pos K. M., Rigaud J.-L., Ruan Z.-S., Sambrook J., Tolner B., Tolner B., Tolner B., Zhang Y.   +19 more
core   +2 more sources

Cell-Penetrating Peptide-Mediated Biomolecule Transportation in Artificial Lipid Vesicles and Living Cells

Molecules
Signal transduction and homeostasis are regulated by complex protein interactions in the intracellular environment. Therefore, the transportation of impermeable macromolecules (nucleic acids, proteins, and drugs) that control protein interactions is ...
Akari Miwa, Koki Kamiya
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

Journal of Lipid Research, 2015
ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about which little mechanistic information is available.
Maria Lindahl, Jitka Petrlova, Jonathan Dalla-Riva, Sebastian Wasserstrom, Catarina Rippe, Joan Domingo-Espin, Dorota Kotowska, Ewa Krupinska, Christine Berggreen, Helena A. Jones, Karl Swärd, Jens O. Lagerstedt, Olga Göransson, Karin G. Stenkula   +13 more
doaj  

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Research and Practice in Thrombosis and Haemostasis, 2019
Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs).
Maaike Schillemans, Marije Kat, Jurjen Westeneng, Anastasia Gangaev, Menno Hofman, Benjamin Nota, Floris P. J. van Alphen, Martin de Boer, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings   +11 more
doaj   +1 more source