Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression [PDF]
Molecular PainTransient Receptor Potential Vanilloid 1 (TRPV1) is a nonselective cation channel expressed by pain-sensing neurons and has been an attractive target for the development of drugs to treat pain.
Robin Vroman +9 more
doaj +5 more sources
Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2 [PDF]
Cell & Bioscience, 2019 Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of atherosclerosis, monocyte-derived dendritic cells (Mo-DCs) respond to inflammatory stimuli, including
Geneviève Hamel-Côté +5 more
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Targeting protein tyrosine phosphatase non-receptor type 6 (PTPN6) as a therapeutic strategy in acute myeloid leukemia. [PDF]
Cell Biol ToxicolAcute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid progenitor cells. Despite advancements in treatment, the prognosis for AML patients remains poor, highlighting the need for novel therapeutic targets. Protein Tyrosine Phosphatase Non-Receptor Type 6 (PTPN6), also known as SHP-1, is a
Wang X, Li Z, Shen J, Liu L.
europepmc +3 more sources
PLoS Genetics, 2021 The regulatory subunits (P60 in insects, P85 in mammals) determine the activation of the catalytic subunits P110 in phosphatidylinositol 3-kinases (PI3Ks) in the insulin pathway for cell proliferation and body growth.
Yu-Qin Di +3 more
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Virulence, 2021 Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf +5 more
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PTPN6 (protein tyrosine phosphatase, non-receptor type 6) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on PTPN6 (protein tyrosine phosphatase, non-receptor type 6), with data on DNA, on the protein encoded, and where the gene is implicated.
A. Beghini, F. Lazzaroni
openaire +3 more sources
BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts. [PDF]
PLoS ONE, 2016 Bone resorption in vertebrates relies on the ability of osteoclasts to assemble F-actin-rich podosomes that condense into podosomal belts, forming sealing zones.
Martin Sztacho +5 more
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Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. [PDF]
PLoS ONE, 2013 BACKGROUND: Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD).
Marianne R Spalinger +5 more
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Journal of Integrative Agriculture, 2023 Enhancing host immunity is an effective way to reduce morbidity in chickens. Heterophil to lymphocyte ratio (H/L) is associated with host disease resistance in birds. Chickens with different H/L levels show different disease resistances.
Jin ZHANG +8 more
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Distinct and overlapping functions of ptpn11 genes in Zebrafish development. [PDF]
PLoS ONE, 2014 The PTPN11 (protein-tyrosine phosphatase, non-receptor type 11) gene encodes SHP2, a cytoplasmic PTP that is essential for vertebrate development. Mutations in PTPN11 are associated with Noonan and LEOPARD syndrome.
Monica Bonetti +6 more
doaj +1 more source