Results 21 to 30 of about 103,807 (98)

Clinical Characteristics and Prognosis of Acute Myeloid Leukemia Patients with Protein Tyrosine Phosphatase Non-Receptor Type 11 Gene Mutation

Pharmacogenomics and Personalized Medicine, 2023
Rui Huang,* Yi-Ting Zhang,* Yu Lin, Ru-Li Pang, Zhi Yang, Wei-Hua Zhao Department of Hematology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China*These ...
Huang R, Zhang YT, Lin Y, Pang RL, Yang Z, Zhao WH   +5 more
doaj  

Multi-omic analyses reveal PTPN6’s impact on tumor immunity across various cancers

Scientific Reports
Protein Tyrosine Phosphatase Non-Receptor Type 6 (PTPN6) plays a crucial regulatory role in cellular processes and has been implicated in oncogenesis.
Yuchen Zhong, Weiyuan Zhang, Chaojing Zheng, Hongyu Wu, Jun Luo, Ziming Yuan, Hao Zhang, Chunlin Wang, Haiyang Feng, Meng Wang, Qian Zhang, Haixing Ju, Guiyu Wang   +12 more
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Effects of PTPN6 Gene Knockdown in SKM-1 Cells on Apoptosis, Erythroid Differentiation and Inflammations

Current Issues in Molecular Biology
Objective: Protein tyrosine phosphatase non-receptor type 6 (PTPN6) is a cytoplasmic phosphatase that acts as a key regulatory protein in cell signaling to control inflammation and cell death.
Li Yu, Xiaoli Gu, Pengjie Chen, Rui Yang, Yonggang Xu, Xiupeng Yang   +5 more
doaj   +1 more source

Persea americana Peel: A Promising Source of Nutraceutical for the Mitigation of Cardiovascular Risk in Arthritic Rats Through the Gut–Joint Axis

Biomolecules
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by the inflammation of synovial fluid. The incidence of cardiovascular diseases (CVDs) is increasing in RA patients. This research is the first report to investigate the
Doha A. Mohamed, Asmaa A. Ramadan, Hoda B. Mabrok, Gamil E. Ibrahim, Shaimaa E. Mohammed   +4 more
doaj   +1 more source

Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation

Infectious Agents and Cancer
Introduction Human T-cell Lymphotropic virus type 1 (HTLV-1) belongs to retroviridae which is connected to two major diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T-cell leukemia/lymphoma (ATLL).
Arash Letafati, Atefeh Bahavar, Alijan Tabarraei, Mehdi Norouzi, Abdollah Amiri, Sayed-Hamidreza Mozhgani   +5 more
doaj   +1 more source

Protein Profiling of Isolated Leukocytes, Myofibroblasts, Epithelial, Basal, and Endothelial Cells from Normal, Hyperplastic, Cancerous, and Inflammatory Human Prostate Tissues

Journal of Cancer, 2010
In situ neoplastic prostate cells are not lethal unless they become invasive and metastatic. For cells to become invasive, the prostate gland must undergo degradation of the basement membrane and disruption of the basal cell layer underneath the luminal ...
Zahraa I. Khamis, Kenneth A. Iczkowski, Ziad J. Sahab, Qing-Xiang Amy Sang
doaj  

Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression

Discover Oncology
Background Cancer remains a leading cause of mortality worldwide, characterized by complex genetic and molecular alterations. The Protein Tyrosine Phosphatase Non-Receptor Type 6 (PTPN6), also known as SHP-1, plays a critical role in regulating immune ...
Xiaohui Wang, Mumtaz Hussain, Qurat ul Ain, Madiha Zaynab, Mostafa A. Abdel-Maksoud, Taghreed N. Almana, Saeedah Almutair, Abdulaziz Alamri, Ibrahim A. Saleh, Naser Zomot, Wahidah H. Al-Qahtani, Faisal Siddique, Yasir Hameed   +12 more
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Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses

Gut Microbes
Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 (PTPN2), is associated with altered microbiome composition in both human subjects and mice.
Pritha Chatterjee, Marianne R. Spalinger, Charly Acevedo, Alina N. Santos, Casey M. Gries, Salomon M. Manz, Vinicius Canale, Ali Shawki, Anica Sayoc-Becerra, Hillmin Lei, Meli’sa S. Crawford, Lars Eckmann, James Borneman, Declan F. McCole   +13 more
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SHP2 as a pivotal modulator of the tumor microenvironment in gastrointestinal cancers: from mechanisms to targeted therapies. [PDF]

J Transl Med
Wang S, Zhao X, Dong J, Zhang J, Wang Y, Jin H, Jiang X, Chen L, Zhang M, Ji L, Zhao Y.   +10 more
europepmc   +1 more source

Glycosaminoglycans in axon growth and regeneration: molecular mechanisms and therapeutic implications. [PDF]

Front Mol Biosci
Sakamoto K, Nagai Y, Kadomatsu K.
europepmc   +1 more source