Results 11 to 20 of about 103,807 (98)

Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis. [PDF]

PLoS ONE, 2013
Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative regulator of interferon-gamma (IFN-γ)-induced responses, and IFN-γ stimulation of immune cells is a ...
Belén Morón, Marianne Spalinger, Stephanie Kasper, Kirstin Atrott, Isabelle Frey-Wagner, Michael Fried, Declan F McCole, Gerhard Rogler, Michael Scharl   +8 more
doaj   +1 more source

Hyperbaric oxygen treatment on keloid tumor immune gene expression

Chinese Medical Journal, 2021
. Background:. Hyperbaric oxygen treatment (HBOT) has been demonstrated to influence the keloid recurrence rate after surgery and to relieve keloid symptoms and other pathological processes in keloids.
Chun-Hu Wang, Meng-Jie Shan, Hao Liu, Yan Hao, Ke-Xin Song, Huan-Wen Wu, Tian Meng, Cheng Feng, Zheng Qi, Zhi Wang, You-Bin Wang, Ning-Ning Wang   +11 more
doaj   +1 more source

Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens

BMC Genomics, 2020
Background The Tibial dyschondroplasia (TD) in fast-growing chickens is mainly caused by improper blood circulation. The exact mechanism underlying angiogenesis and vascularization in tibial growth plate of broiler chickens remains unclear.
Ali Raza Jahejo, Ding Zhang, Sheng Niu, Raza Ali Mangi, Afrasyab Khan, Muhammad Farhan Qadir, Ajab Khan, Huan-chun Chen, Wen-xia Tian   +8 more
doaj   +1 more source

Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases

Frontiers in Immunology, 2019
Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), and rheumatoid arthritis (RA) are chronic inflammatory diseases in which abnormalities of B cell function play a central role.
Sarah Y. Weißenberg, Sarah Y. Weißenberg, Franziska Szelinski, Franziska Szelinski, Eva Schrezenmeier, Ana-Luisa Stefanski, Annika Wiedemann, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Anna Welle, Annemarie Jungmann, Karl Nordström, Jörn Walter, Juliana Imgenberg-Kreuz, Gunnel Nordmark, Lars Rönnblom, Prathyusha Bachali, Michelle D. Catalina, Amrie C. Grammer, Peter E. Lipsky, Andreia C. Lino, Andreia C. Lino, Thomas Dörner, Thomas Dörner   +24 more
doaj   +1 more source

Aberrant promoter�2 methylation‑mediated downregulation of protein tyrosine phosphatase, non‑receptor type�6, is associated with progression of esophageal squamous cell carcinoma

Molecular Medicine Reports, 2019
The human protein tyrosine phosphatase, non‑receptor type 6 (PTPN6) gene is located on chromosome 12p13 and encodes an Mr 68,000 non‑receptor type protein‑tyrosine phosphatase. The PTPN6 gene has been considered as a candidate tumor suppressor in hematological and solid malignancies, and promoter methylation may be an epigenetic modification silencing ...
Lei, Liu, Shaowei, Zhang, Xinbo, Liu, Junfeng, Liu   +3 more
openaire   +3 more sources

Differential expression of protein tyrosine phosphatase, non-receptor type 6 in human epithelial ovarian cancer.

, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors ...
openaire   +2 more sources

Interference of protein tyrosine phosphatase non-receptor type 22 inhibits NLRP3 inflammasome activation to alleviate inflammation after cerebral hemorrhage in rats

Di-san junyi daxue xuebao, 2019
Objective To investigate the role of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in inflammatory response following intracerebral hemorrhage (ICH) in rats and explore the mechanism that mediates its effect.
WANG Lu, ZHANG Li, XIAO Han, GAN Hui, CHEN Hui   +4 more
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Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis

Frontiers in Cellular and Infection Microbiology, 2018
A shared genetic pre-disposition, chronic inflammation, and treatment with similar biologics between Rheumatoid arthritis (RA) and Crohn's disease (CD) have intrigued us to investigate whether the two disorders share trigger association or possible ...
Robert C. Sharp, Shazia A. Beg, Saleh A. Naser   +2 more
doaj   +1 more source

MOESM1 of Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2

, 2019
Additional file 1. Additional figures.
Hamel-Côté, Geneviève, Lapointe, Fanny, Véronneau, Steeve, Mayhue, Marian, Rola-Pleszczynski, Marek, Stankova, Jana   +5 more
openaire   +1 more source

5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells

Current Issues in Molecular Biology
Epigenetic modifications, including aberrant DNA methylation occurring at the promoters of oncogenes and oncosuppressor genes and histone modifications, can contribute to carcinogenesis.
Michele Di Crosta, Andrea Arena, Rossella Benedetti, Maria Saveria Gilardini Montani, Mara Cirone   +4 more
doaj   +1 more source