Results 251 to 260 of about 277,071 (303)
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2004
The process of reversible phosphorylation is perhaps the cell's most prevalent means of regulation at the molecular level. It has been estimated that up to 30% of all cellular proteins are phosphorylated, and phosphorylation has been shown to play a crucial regulatory role in such diverse cellular events as metabolism, growth and differentiation ...
Matthew L, Jones, Alastair W, Poole
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The process of reversible phosphorylation is perhaps the cell's most prevalent means of regulation at the molecular level. It has been estimated that up to 30% of all cellular proteins are phosphorylated, and phosphorylation has been shown to play a crucial regulatory role in such diverse cellular events as metabolism, growth and differentiation ...
Matthew L, Jones, Alastair W, Poole
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Frontiers in Bioscience, 2002
The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade.
T, Mustelin +7 more
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The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade.
T, Mustelin +7 more
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Protozoan protein tyrosine phosphatases
International Journal for Parasitology, 2008The aim of this review is to provide a synthesis of the published experimental data on protein tyrosine phosphatases from parasitic protozoa, in silico analysis based on the availability of completed genomes and to place available data for individual phosphatases from different unicellular parasites into the comparative and evolutionary context.
Alexandra V, Andreeva +1 more
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Drosophila protein tyrosine phosphatases
Seminars in Cell Biology, 1993Seven protein tyrosine phosphatase (PTPase) genes have been identified in the fruit-fly Drosophila melanogaster. Four of these genes encode receptor-linked PTPases (R-PTPs) that are expressed on central nervous system axons in the embryo. Each axonal R-PTP has an extracellular domain that is homologous to vertebrate adhesion molecules and to identified
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Protein Tyrosine Phosphatases in Autoimmunity
Annual Review of Immunology, 2008Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant
Torkel, Vang +5 more
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Protein tyrosine phosphatase: enzymatic assays
Methods, 2005Activity assays for tyrosine phosphatases are based on the hydrolysis of a arylphosphate moiety from a synthetic substrate yielding a spectroscopically active product. Many different substrates can be used for these assays with p-nitrophenyl phosphate (pNPP), fluorescein diphosphate (FDP), and 6,8-difluoro-4-methylumbellyferyl phosphate (DiFMUP) being ...
Jacqueline, Montalibet +2 more
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1996
Protein tyrosine phosphorylation and dephosphorylation are believed to be key regulatory mechanisms in the control of signal transduction, cell proliferation, differentiation, and neoplastic transformation [1–4]. The net cellular level of tyrosine phosphorylation is maintained dynamically by the opposing actions of protein tyrosine kinases (PTKs) and ...
Yi-Fan Zhai +3 more
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Protein tyrosine phosphorylation and dephosphorylation are believed to be key regulatory mechanisms in the control of signal transduction, cell proliferation, differentiation, and neoplastic transformation [1–4]. The net cellular level of tyrosine phosphorylation is maintained dynamically by the opposing actions of protein tyrosine kinases (PTKs) and ...
Yi-Fan Zhai +3 more
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Protein tyrosine phosphatases take off
Nature Structural & Molecular Biology, 1995Protein tyrosine phosphatases (PTPs) are a family of signal transduction enzymes that dephosphorylate phosphotyrosine containing proteins. Structural and kinetic studies provide a molecular understanding of how these enzymes regulate a wide range of intracellular processes.
D, Barford, Z, Jia, N K, Tonks
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Protein-tyrosine phosphatases and cancer
Nature Reviews Cancer, 2006Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs).
Arne, Ostman +2 more
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Protein Tyrosine Phosphatases in Osteoclasts
Critical Reviews™ in Eukaryotic Gene Expression, 2007Osteoclasts are large cells derived from the monocyte-macrophage hematopoietic cell lineage, whose primary function is to degrade bone in various physiological contexts. Reversible phosphorylation of tyrosine residues in proteins is known to play significant roles in regulating the function of osteoclasts, much as it does in other cell types.
Shira, Granot-Attas +2 more
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