Results 251 to 260 of about 3,688,591 (305)

Protein Tyrosine Phosphatases in Autoimmunity

Annual Review of Immunology, 2008
Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant
Torkel, Vang, Ana V, Miletic, Yutaka, Arimura, Lutz, Tautz, Robert C, Rickert, Tomas, Mustelin   +5 more
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Protein Tyrosine Phosphatases in Osteoclasts

Critical Reviews™ in Eukaryotic Gene Expression, 2007
Osteoclasts are large cells derived from the monocyte-macrophage hematopoietic cell lineage, whose primary function is to degrade bone in various physiological contexts. Reversible phosphorylation of tyrosine residues in proteins is known to play significant roles in regulating the function of osteoclasts, much as it does in other cell types.
Shira, Granot-Attas, Hilla, Knobler, Ari, Elson   +2 more
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Protein-tyrosine phosphatases and cancer

Nature Reviews Cancer, 2006
Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs).
Arne, Ostman, Carina, Hellberg, Frank D, Böhmer   +2 more
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Protein Tyrosine Phosphatases and their Inhibitors

Current Medicinal Chemistry, 2005
Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors.
Purushottam M, Dewang, Nai-Mu, Hsu, Shao-Zheng, Peng, Wen-Ren, Li   +3 more
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Protozoan protein tyrosine phosphatases

International Journal for Parasitology, 2008
The aim of this review is to provide a synthesis of the published experimental data on protein tyrosine phosphatases from parasitic protozoa, in silico analysis based on the availability of completed genomes and to place available data for individual phosphatases from different unicellular parasites into the comparative and evolutionary context.
Alexandra V, Andreeva, Mikhail A, Kutuzov   +1 more
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Protein tyrosine phosphatases in signaling

Current Opinion in Cell Biology, 1996
During the past few years, molecular cloning has established the existence of a structurally diverse family of intracellular and transmembrane protein tyrosine phosphatases (PTPases). The importance of PTPases in signaling is best understood in three model systems: the mammalian transmembrane CD45 PTPase, the Drosophila Src homology (SH)2 domain ...
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Assays for Protein-Tyrosine Phosphatases

2002
Many studies have implicated protein-tyrosine phosphatases (PTPases) as important regulators of cellular functions and as potential drug targets. This has led to an increased interest in the development of precise assays for detailed mechanistic studies of PTPases, rapid assays for high-throughput PTPase inhibitor screening, and more biologically ...
Daniel F, McCain, Zhong-Yin, Zhang
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Drosophila protein tyrosine phosphatases

Seminars in Cell Biology, 1993
Seven protein tyrosine phosphatase (PTPase) genes have been identified in the fruit-fly Drosophila melanogaster. Four of these genes encode receptor-linked PTPases (R-PTPs) that are expressed on central nervous system axons in the embryo. Each axonal R-PTP has an extracellular domain that is homologous to vertebrate adhesion molecules and to identified
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Drug Discovery and Protein Tyrosine Phosphatases

Current Medicinal Chemistry, 2009
Protein tyrosine phosphatases (PTPs) play a critical role in physiological signaling pathways by controlling the level of tyrosine phosphorylation. The past decade has seen a vast increase in both academic and industrial interest in PTPs and their relevance as potential therapeutic targets, with several PTP inhibitors recently entering clinical trials.
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Protein tyrosine phosphatases

1996
Protein tyrosine phosphorylation and dephosphorylation are believed to be key regulatory mechanisms in the control of signal transduction, cell proliferation, differentiation, and neoplastic transformation [1–4]. The net cellular level of tyrosine phosphorylation is maintained dynamically by the opposing actions of protein tyrosine kinases (PTKs) and ...
Yi-Fan Zhai, Julie J. Wirth, Clifford W. Welsch, Walter J. Esselman   +3 more
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