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Receptor Protein-Tyrosine Phosphatase Dimerization
2003Publisher Summary This chapter discusses that the receptor protein-tyrosine phosphatases (RPTPs) form a subfamily of the classical protein-tyrosine phosphatase family. It is established that the enzymatic counterparts of the RPTPs, the receptor protein-tyrosine kinases (RPTKs), are regulated by ligand binding to their extracellular domain, for ...
Jeroen, den Hertog +3 more
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2000
The importance of tyrosine phosphorylation in diverse cellular processes such as cell growth, gene expression, metabolism, differentiation, cytoskeletal dynamics, and cell motility was discovered primarily through studies of the protein tyrosine kinases (PTKs).
Cynthia V. Stauffacher +1 more
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The importance of tyrosine phosphorylation in diverse cellular processes such as cell growth, gene expression, metabolism, differentiation, cytoskeletal dynamics, and cell motility was discovered primarily through studies of the protein tyrosine kinases (PTKs).
Cynthia V. Stauffacher +1 more
openaire +1 more source
Assays for Protein-Tyrosine Phosphatases
2002Many studies have implicated protein-tyrosine phosphatases (PTPases) as important regulators of cellular functions and as potential drug targets. This has led to an increased interest in the development of precise assays for detailed mechanistic studies of PTPases, rapid assays for high-throughput PTPase inhibitor screening, and more biologically ...
Daniel F, McCain, Zhong-Yin, Zhang
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1998
Abstract The first descriptions of PTPases in cell and tissue extracts provided evidence that they were distinct from other protein phosphatases because of their substrate specificity, neutral pH optimum, resistance to EDT A, and unique inhibition by low concentrations of zinc or vanadate [33].
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Abstract The first descriptions of PTPases in cell and tissue extracts provided evidence that they were distinct from other protein phosphatases because of their substrate specificity, neutral pH optimum, resistance to EDT A, and unique inhibition by low concentrations of zinc or vanadate [33].
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Protein tyrosine phosphatases in signaling
Current Opinion in Cell Biology, 1996During the past few years, molecular cloning has established the existence of a structurally diverse family of intracellular and transmembrane protein tyrosine phosphatases (PTPases). The importance of PTPases in signaling is best understood in three model systems: the mammalian transmembrane CD45 PTPase, the Drosophila Src homology (SH)2 domain ...
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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
Nature Reviews Drug Discovery, 2023Nunzio Bottini
exaly
Receptor protein tyrosine phosphatases
2003The receptor protein-tyrosine phosphatases (RPTPs) form a subfamily of the classical protein-tyrosine phosphatases (PTPs). RPTPs are interesting because they have the ability to signal across the cell membrane due to their topology. Evidence is accumulating that RPTPs play important roles during embryonic development and in human disease.
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