Results 41 to 50 of about 42,408 (158)
Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana
Frontiers in Cellular and Infection Microbiology, 2021 Protein phosphorylation and dephosphorylation are increasingly recognized as important processes for regulating multiple physiological mechanisms.
Alma Reyna Escalona-Montaño +10 more
doaj +1 more source
Dual-Specificity Phosphatases and Kidney Diseases
Kidney Diseases, 2021 Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues.
Haiyang Li +4 more
doaj +1 more source
Molecules, 2013 A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the micromolar range.
Wen-Long Wang +16 more
doaj +1 more source
Expression Profile of Tyrosine Phosphatases in HER2 Breast Cancer Cells and Tumors
Cellular Oncology, 2010 Background: HER2-overexpression promotes malignancy by modulating signalling molecules, which include PTPs/DSPs (protein tyrosine and dual-specificity phosphatases). Our aim was to identify PTPs/DSPs displaying HER2-associated expression alterations.
Maria Antonietta Lucci +5 more
doaj +1 more source
Cell Reports, 2019 Summary: Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition and dynamics of the PD-1 and BTLA coinhibitory signalosomes in primary ...
Javier Celis-Gutierrez +11 more
doaj +1 more source
Minimally disruptive optical control of protein tyrosine phosphatase 1B
Nature Communications, 2020 Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its
Akarawin Hongdusit +3 more
doaj +1 more source
Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf. [PDF]
PLoS ONE, 2016 The extracellular signal-regulated kinase (ERK) is one of the principal hub proteins that transmit growth signals from upstream oncogene products including Ras and BRaf to downstream effector proteins.
Noriyuki Kawabata, Michiyuki Matsuda
doaj +1 more source
The receptor PTPRU is a redox sensitive pseudophosphatase
Nature Communications, 2020 Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may ...
Iain M. Hay +5 more
doaj +1 more source
Protein Tyrosine Phosphatase 1B in Hematopoiesis [PDF]
Cell Cycle, 2006 Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase best known for its role in insulin signaling. Despite the fact that it is highly expressed in hematopoietic tissues and has been shown to downregulate cytokine receptor signaling, no physiological role for PTP-1B in immune regulation had been reported. Our recent
Krista M, Heinonen, Michel L, Tremblay
openaire +2 more sources
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases
Cell & Bioscience, 2019 Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases (PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and phosphor-tyrosine on mitogen-activated protein kinases (MAPKs), and hence are also ...
Tao Ding +8 more
doaj +1 more source