Frontiers in Pharmacology, 2015 The transmembrane protein Ci-VSP from the ascidian Ciona intestinalis was described as first member of a fascinating family of enzymes, the voltage sensitive phosphatases (VSPs). Ci-VSP and its voltage-activated homologs from other species are stimulated
Kirstin eHobiger, Thomas eFriedrich
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The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]
, 2009 Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi +2 more
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Research advances of dual-specificity phosphatases in kidney disease
Linchuang shenzangbing zazhi, 2021 Belonging to the family of protein tyrosine phosphatases,DUSPs（dual-specificity phosphatases）can dephosphorylate both serine/threonine and tyrosine residues concurrently.In recent years,with the in-depth study of DUSPs,they have been implicated as major ...
杜宇, 章波, 赵景宏
doaj
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
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Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets? [PDF]
BMB Reports, 2012 Obesity is a worldwide epidemic as well as being a major riskfactor for diabetes, cardiovascular diseases and several types ofcancers. Obesity is mainly due to the overgrowth of adiposetissue arising from an imbalance between energy intake andenergy ...
Kwang-Hee Bae
doaj
Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases
Molecules, 2018 Proper control of the phosphotyrosine content in signal transduction proteins is essential for normal cell behavior and is lost in many pathologies. Attempts to normalize aberrant tyrosine phosphorylation levels in disease states currently involve either
Wiljan Hendriks +3 more
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Central regulation of metabolism by protein tyrosine phosphatases
Frontiers in Neuroscience, 2013 Protein tyrosine phosphatases (PTPs) are important regulators of intracellular signaling pathways via the dephosphorylation of phosphotyrosyl residues on various receptor and non-receptor substrates.
Ryan eTsou, Kendra eBence
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Roles of Histidine Kinases and Histidine Phosphatases in Cancer
Chinese Journal of Lung Cancer, 2021 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis ...
Yafang DONG +3 more
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Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]
, 2018 Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika +3 more
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Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
, 2009 We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon +54 more
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