Results 21 to 30 of about 41,275 (256)
Frontiers in Cellular and Infection Microbiology, 2022 The human oral cavity harbors approximately 1,000 microbial species, and dysbiosis of the microflora and imbalanced microbiota-host interactions drive many oral diseases, such as dental caries and periodontal disease.
Liang Ren +3 more
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Neural Plasticity, 2018 Degeneration of cortical and spinal motor neurons is the typical feature of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease for which a pathogenetic role for the Cu/Zn superoxide dismutase (SOD1) has been demonstrated.
Cinzia Mallozzi +3 more
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Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. [PDF]
PLoS ONE, 2011 Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular
Lalima L Madan +5 more
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Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase [PDF]
Biochemical Journal, 1995 We have isolated the murine cDNA homologue of the human protein tyrosine phosphatase PTP-PEST (MPTP-PEST) from an 18.5-day mouse embryonic kidney library. The cDNA isolated has a single open reading frame predicting a protein of 775 amino acids. When expressed in vitro as a glutathione S-transferase fusion protein, the catalytic domain (residues 1-453)
Charest, Alain +3 more
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Frontiers in Pharmacology, 2015 The transmembrane protein Ci-VSP from the ascidian Ciona intestinalis was described as first member of a fascinating family of enzymes, the voltage sensitive phosphatases (VSPs). Ci-VSP and its voltage-activated homologs from other species are stimulated
Kirstin eHobiger, Thomas eFriedrich
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Research advances of dual-specificity phosphatases in kidney disease
Linchuang shenzangbing zazhi, 2021 Belonging to the family of protein tyrosine phosphatases,DUSPs（dual-specificity phosphatases）can dephosphorylate both serine/threonine and tyrosine residues concurrently.In recent years,with the in-depth study of DUSPs,they have been implicated as major ...
杜宇, 章波, 赵景宏
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Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases
Molecules, 2018 Proper control of the phosphotyrosine content in signal transduction proteins is essential for normal cell behavior and is lost in many pathologies. Attempts to normalize aberrant tyrosine phosphorylation levels in disease states currently involve either
Wiljan Hendriks +3 more
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Protein tyrosine phosphatases and signalling [PDF]
Journal of Endocrinology, 2005 A cornerstone of many cell-signalling events rests on reversible phosphorylation of tyrosine residues on proteins. The reversibility relies on the coordinated actions of protein tyrosine kinases and protein tyrosine phosphatases (PTPs), both of which exist as large protein families. This review focuses on the rapidly evolving field of the PTPs.
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Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets? [PDF]
BMB Reports, 2012 Obesity is a worldwide epidemic as well as being a major riskfactor for diabetes, cardiovascular diseases and several types ofcancers. Obesity is mainly due to the overgrowth of adiposetissue arising from an imbalance between energy intake andenergy ...
Kwang-Hee Bae
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Central regulation of metabolism by protein tyrosine phosphatases
Frontiers in Neuroscience, 2013 Protein tyrosine phosphatases (PTPs) are important regulators of intracellular signaling pathways via the dephosphorylation of phosphotyrosyl residues on various receptor and non-receptor substrates.
Ryan eTsou, Kendra eBence
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