Bacterial Protein Tyrosine Phosphatases as Possible Targets for Antimicrobial Therapies in Response to Antibiotic Resistance [PDF]
Antioxidants, 2022 The review is focused on the bacterial protein tyrosine phosphatases (PTPs) utilized by bacteria as virulence factors necessary for pathogenicity. The inhibition of bacterial PTPs could contribute to the arrest of the bacterial infection process.
Alicja Kuban-Jankowska +2 more
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Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance [PDF]
Cell Reports, 2023 Summary: Elucidating the mechanisms of resistance to immunotherapy and developing strategies to improve its efficacy are challenging goals. Bioinformatics analysis demonstrates that high CDK6 expression in melanoma is associated with poor progression ...
Xueliang Gao +17 more
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Protein tyrosine phosphatases in skeletal development and diseases [PDF]
Bone Research, 2022 Skeletal development and homeostasis in mammals are modulated by finely coordinated processes of migration, proliferation, differentiation, and death of skeletogenic cells originating from the mesoderm and neural crest.
Huiliang Yang +3 more
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PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis [PDF]
Nature Communications, 2017 Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context.
Cristiano Sacchetti +15 more
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Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies [PDF]
CellsAdvances in immunotherapy have brought significant therapeutic benefits to many cancer patients. Nonetheless, many cancer types are refractory to current immunotherapeutic approaches, meaning that further targets are required to increase the number of ...
Robert J. Salmond
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Sequence – dynamics – function relationships in protein tyrosine phosphatases [PDF]
QRB DiscoveryProtein tyrosine phosphatases (PTPs) are crucial regulators of cellular signaling. Their activity is regulated by the motion of a conserved loop, the WPD-loop, from a catalytically inactive open to a catalytically active closed conformation.
Rory M. Crean +4 more
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Protein tyrosine phosphatases: emerging role in cancer therapy resistance [PDF]
Cancer CommunicationsBackground Tyrosine phosphorylation of intracellular proteins is a post‐translational modification that plays a regulatory role in signal transduction during cellular events.
Min Zhao +6 more
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Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis [PDF]
Microorganisms, 2020 Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis (Mtb). According to the World Health Organization, an estimated 10 million people developed TB in 2018.
Kasi Viswanatharaju Ruddraraju +2 more
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Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases [PDF]
Acta Pharmaceutica Sinica BProtein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms’ homeostasis and function.
Ao Wang +3 more
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The role of receptor‐type protein tyrosine phosphatases in cancer
Precision Medical Sciences, 2023 Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes
Zhengyuan Lv +4 more
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