Results 11 to 20 of about 41,275 (256)
The role of receptor‐type protein tyrosine phosphatases in cancer
Precision Medical Sciences, 2023 Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes
Zhengyuan Lv +4 more
doaj +1 more source
The progress of research into pseudophosphatases
Frontiers in Public Health, 2022 Pseudophosphatases are a class of phosphatases that mutate at the catalytically active site. They play important parts in many life processes and disorders, e.g., cell apoptosis, stress reaction, tumorigenesis, axon differentiation, Charcot-Marie-Tooth ...
Deqiang Liu +5 more
doaj +1 more source
Biomolecules, 2021 Protein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases.
Raju V. S. Rajala +4 more
doaj +1 more source
Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis
Haematologica, 2020 There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer +5 more
doaj +1 more source
Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease
Frontiers in Cardiovascular Medicine, 2021 Peripheral artery disease is caused by atherosclerosis of lower extremity arteries leading to the loss of blood perfusion and subsequent critical ischemia. The presence of diabetes mellitus is an important risk factor that greatly increases the incidence,
Clément Mercier +2 more
doaj +1 more source
Frontiers in Microbiology, 2014 Signal transduction in eukaryotes is generally transmitted through phosphorylation cascades that involve a complex interplay of transmembrane receptors, protein kinases, phosphatases and their targets.
Lei eShi +9 more
doaj +1 more source
Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP
Frontiers in Cell and Developmental Biology, 2021 Protein tyrosine phosphatases (PTPs) are modulators of cellular functions such as differentiation, metabolism, migration, and survival. PTPs antagonize tyrosine kinases by removing phosphate moieties from molecular signaling residues, thus inhibiting ...
Fang Hao +4 more
doaj +1 more source
Life, 2021 Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj +1 more source
Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. [PDF]
PLoS ONE, 2015 Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P ...
Bryan M Zhao +8 more
doaj +1 more source
Protein Tyrosine Phosphatase Assays [PDF]
Current Protocols in Immunology, 2011 AbstractTyrosine phosphorylation and dephosphorylation of proteins play a critical role in many processes of the immune system, from early development to fully differentiated effector function. Since the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) determine the steady‐state level of tyrosine ...
openaire +2 more sources