Results 31 to 40 of about 79,142 (299)

Structural Insights into Protein Regulation by Phosphorylation and Substrate Recognition of Protein Kinases/Phosphatases

Life, 2021
Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj   +1 more source

Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [PDF]

, 2008
Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri, Sami, Jeon, Mili, Nguyen, Huong, Zinn, Kai   +3 more
core   +4 more sources

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]

, 2016
Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H, Chang, Jenny, Den Hollander, Petra, Fuqua, Suzanne, Hartman, Zachary C, Hill, Jamal, Hilsenbeck, Susan G, Kent Osborne, C, Mazumdar, Abhijit, Mills, Gordon B, Poage, Graham M, Shepherd, Jonathan, Tsimelzon, Anna, Zhang, Yun   +13 more
core   +2 more sources

Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. [PDF]

PLoS ONE, 2015
Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P ...
Bryan M Zhao, Sarah L Keasey, Joseph E Tropea, George T Lountos, Beverly K Dyas, Scott Cherry, Sreejith Raran-Kurussi, David S Waugh, Robert G Ulrich   +8 more
doaj   +1 more source

Protein Tyrosine and Serine/Threonine Phosphorylation in Oral Bacterial Dysbiosis and Bacteria-Host Interaction

Frontiers in Cellular and Infection Microbiology, 2022
The human oral cavity harbors approximately 1,000 microbial species, and dysbiosis of the microflora and imbalanced microbiota-host interactions drive many oral diseases, such as dental caries and periodontal disease.
Liang Ren, Daonan Shen, Chengcheng Liu, Yi Ding   +3 more
doaj   +1 more source

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45 [PDF]

, 2012
Many cellular signaling events are regulated by tyrosine phosphorylation and mediated by the opposing actions of protein tyrosine kinases and phosphatases.
Barrios, Amy M., Bavari, Sina, Bottini, Nunzio, Damle, Sagar S., Falk, Matthew D., Kaltcheva, Teodora, Mitra, Sayantan, Panchal, Rekha G., Ruble, David, Stanford, Stephanie M., Walker, Logan M., Wu, Dennis J., Zhang, Sheng, Zhang, Zhong-Yin   +13 more
core   +1 more source

Activation of Phosphotyrosine-Mediated Signaling Pathways in the Cortex and Spinal Cord of SOD1G93A, a Mouse Model of Familial Amyotrophic Lateral Sclerosis

Neural Plasticity, 2018
Degeneration of cortical and spinal motor neurons is the typical feature of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease for which a pathogenetic role for the Cu/Zn superoxide dismutase (SOD1) has been demonstrated.
Cinzia Mallozzi, Alida Spalloni, Patrizia Longone, Maria Rosaria Domenici   +3 more
doaj   +1 more source

Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. [PDF]

PLoS ONE, 2011
Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular
Lalima L Madan, S Veeranna, Khader Shameer, Chilamakuri C S Reddy, R Sowdhamini, B Gopal   +5 more
doaj   +1 more source

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. [PDF]

, 2017
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets.
Aleshin, Alexander E, Ardecky, Robert J, Bankston, Laurie A, Barquilla, Antonio, Bliss, Matthew R, Bobkov, Andrey A, Bottini, Nunzio, Cadwell, Gregory W, Chung, Thomas DY, Ganji, Santhi R, Hedrick, Michael P, Khare, Shilpi, Kiselar, Janna, Liddington, Robert C, Liu, Yingge, Mustelin, Tomas, Pinkerton, Anthony B, Schenk, Simon, Stanford, Stephanie M, Yamamoto, Fusayo, Yu, Jinghua, Zhang, Vida, Zou, Jiwen   +22 more
core   +2 more sources

Protein Tyrosine Phosphatase Assays [PDF]

Current Protocols in Immunology, 2011
AbstractTyrosine phosphorylation and dephosphorylation of proteins play a critical role in many processes of the immune system, from early development to fully differentiated effector function. Since the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) determine the steady‐state level of tyrosine ...
openaire   +2 more sources