Results 31 to 40 of about 42,408 (158)

A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. [PDF]

PLoS ONE, 2013
Alterations in function of the neurotrophin BDNF are associated with neurodegeneration, cognitive decline, and psychiatric disorders. BDNF promotes axonal outgrowth and branching, regulates dendritic tree morphology and is important for axonal ...
Malene Ambjørn, Véronique Dubreuil, Federico Miozzo, Fabienne Nigon, Bente Møller, Shohreh Issazadeh-Navikas, Jacob Berg, Michael Lees, Jan Sap   +8 more
doaj   +1 more source

α,α-Difluoro-β-ketophosphonates on a tetraazamacrocyclic platform: Synthesis and inhibitory activity against protein tyrosine phosphatases

Доповiдi Нацiональної академiї наук України
The present study offers a new approach for designing inhibitors of protein tyrosine phosphatases. We have synthesized the cyclam derivatives with α,α-difluoro-β-ketophosphonate fragments covalently attached to tetraazamacrocyclic scaffold, which is ...
D. I. Khavrienko, O. L. Kobzar, M.V. Shevchuk, V.D. Romanenko, S.M. Kobelev, A.D. Averin, I.P. Beletskaya, A. I. Vovk, V.P. Kukhar   +8 more
doaj   +1 more source

Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2. [PDF]

PLoS ONE, 2014
The mitogen-activation protein kinase ERK2 is tightly regulated by multiple phosphatases, including those of the kinase interaction motif (KIM) PTP family (STEP, PTPSL and HePTP).
Dana M Francis, Dorothy Koveal, Antoni Tortajada, Rebecca Page, Wolfgang Peti   +4 more
doaj   +1 more source

Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells

Frontiers in Immunology, 2021
The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response.
Feiling Xie, Feiling Xie, Hongmei Dong, Hongmei Dong, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang   +7 more
doaj   +1 more source

Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?

Frontiers in Cell and Developmental Biology, 2023
Protein tyrosine phosphatases, together with protein tyrosine kinases, control many molecular signaling steps that control life at cellular and organismal levels. Impairing alterations in the genes encoding the involved proteins is expected to profoundly
Wiljan J. A. J. Hendriks, Remco T. P. van Cruchten, Rafael Pulido, Rafael Pulido   +3 more
doaj   +1 more source

Protein Tyrosine Phosphatase Assays [PDF]

Current Protocols in Immunology, 2011
AbstractTyrosine phosphorylation and dephosphorylation of proteins play a critical role in many processes of the immune system, from early development to fully differentiated effector function. Since the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) determine the steady‐state level of tyrosine ...
openaire   +2 more sources

From Tyrosine Kinases to Tyrosine Phosphatases: New Therapeutic Targets in Cancers and Beyond

Pharmaceutics
Protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) regulate the level of tyrosine phosphorylation in proteins. PTKs are key enzymes that catalyze the transfer of an ATP phosphoric acid to a tyrosine residue on target protein ...
Yu Zhou, Zhimeng Yao, Yusheng Lin, Hao Zhang   +3 more
doaj   +1 more source

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Nature Communications, 2017
Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context.
Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini   +15 more
doaj   +1 more source

S-Nitrosation of Arabidopsis thaliana Protein Tyrosine Phosphatase 1 Prevents Its Irreversible Oxidation by Hydrogen Peroxide

Frontiers in Plant Science, 2022
Tyrosine-specific protein tyrosine phosphatases (Tyr-specific PTPases) are key signaling enzymes catalyzing the removal of the phosphate group from phosphorylated tyrosine residues on target proteins.
Valérie Nicolas-Francès, Jordan Rossi, Claire Rosnoblet, Carole Pichereaux, Carole Pichereaux, Siham Hichami, Jeremy Astier, Agnès Klinguer, David Wendehenne, Angélique Besson-Bard   +9 more
doaj   +1 more source

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Marine Drugs, 2006
: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against
Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda   +7 more
doaj   +1 more source