Results 51 to 60 of about 42,408 (158)

Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

Nature Communications, 2017
Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). Here the authors describe a method that allows the localized visualization of oxidized intermediates of PTPs inside cells during ...
Ryouhei Tsutsumi, Jana Harizanova, Rabea Stockert, Katrin Schröder, Philippe I. H. Bastiaens, Benjamin G. Neel   +5 more
doaj   +1 more source

Regulatory role of protein tyrosine phosphatases in hematopoiesis and leukemogenesis

Experimental and Molecular Pathology
Protein tyrosine phosphatases (PTPs), pivotal regulators of tyrosine phosphorylation dynamics, orchestrate cellular signaling networks to govern fundamental processes such as hematopoietic stem cell (HSC) quiescence, proliferation, and stress responses ...
Xiaoting Wang, Yuyao Guan, Yizhuo Qin, Zhen Guan, guangsen Xu, Yining Dong, Zhiyuan Lu, Xiuling Zhang, Lei Zheng, Qian Zhou   +9 more
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Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

Pharmaceuticals
In the text, the synthesis and characteristics of the novel ONS-type vanadium (V) complexes with thioanilide derivatives of amino acids are described. They showed the inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1, and SHP2) in the ...
Grzegorz Kazek, Monika Głuch-Lutwin, Barbara Mordyl, Elżbieta Menaszek, Monika Kubacka, Anna Jurowska, Dariusz Cież, Bartosz Trzewik, Janusz Szklarzewicz, Monika A. Papież   +9 more
doaj   +1 more source

Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis

Molecular & Cellular Oncology, 2017
To obtain a global picture of how protein phosphatases are involved in receptor tyrosine kinase (RTK) signaling, we mapped the RTK-phosphatase interactome. Analyses of selected interactions revealed detailed mechanisms of their actions.
Zhong Yao, Igor Stagljar
doaj   +1 more source

Phospho‐Proteomics Identifies D‐Group MAP Kinases as Substrates of the Arabidopsis Tyrosine Phosphatase RLPH2

Plant Direct
Despite being one of the few bona fide plant tyrosine phosphatases, the Arabidopsis thaliana Rhizobiales‐like phosphatase 2 (RLPH2) has no known substrates.
Anne‐Marie Labandera, Ryan Toth, Sierra Mitchell, Jayde J. Johnson, Brooklyn Kurucz, Juliette Puyaubert, Emmanuel Baudouin, R. Glen Uhrig, Greg B. Moorhead   +8 more
doaj   +1 more source

Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow. [PDF]

IUBMB Life, 2023
Tonks NK.
europepmc   +1 more source

Mapping the Chemical Space of Active-Site Targeted Covalent Ligands for Protein Tyrosine Phosphatases. [PDF]

Chembiochem, 2023
Hong SH, Xi SY, Johns AC, Tang LC, Li A, Hum MN, Chartier CA, Jovanovic M, Shah NH.   +8 more
europepmc   +1 more source

Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review). [PDF]

Oncol Rep, 2023
Chen YL, Hsieh CC, Chu PM, Chen JY, Huang YC, Chen CY.   +5 more
europepmc   +1 more source

Protein tyrosine phosphatase inactivation by electrophilic tyrosine modification

Chemical Science
Here, we develop covalent inhibitors that inactivate protein tyrosine phosphatases (PTPs) via electrophilic modification of functional tyrosines.
Madeleine L. Ware, David M. Leace, Zihan Qu, Quentin Schaefer, Sagar D. Vaidya, Mikayla L. Horvath, Zhihong Li, Yunpeng Bai, Zhong-Yin Zhang, Ku-Lung Hsu   +9 more
openaire   +3 more sources

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

Drug Design, Development and Therapy, 2018
Tomasz Kostrzewa,1 Kamlesh K Sahu,2 Magdalena Gorska-Ponikowska,1 Jack A Tuszynski,3 Alicja Kuban-Jankowska1 1Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland; 2Department of Medical Microbiology and Immunology, University ...
Kostrzewa T, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Kuban-Jankowska A   +4 more
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